Evidence map›Paper›PMID 25305756›Full record

SynthesisNature genetics2014

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.

Krzysztof Kiryluk, Yifu Li, Francesco Scolari, Simone Sanna-Cherchi, Murim Choi, Miguel Verbitsky, David Fasel, Sneh Lata, Sindhuri Prakash, Samantha Shapiro and 82 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 369 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
369citing papers in PubMed, 9 pooled it
24.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

369 citing papers in PubMed, 9 syntheses or guidelines pooled it, 613 citations in OpenAlex.

  1. Pooled it
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  8. Guideline
  9. Pooled it
  10. Trial
  11. Trial
  12. Article
  13. IgA nephropathy management: what does the future hold?Kidney international supplements · 2026
    Review
  14. Review
  15. Review
  16. Atlas of glomerular disease-specific genetic effects on blood transcriptome.medRxiv : the preprint server for health sciences · 2026
    Article
  17. Article
  18. Review
  19. Association of Complement Genetics with Outcomes in IgA Nephropathy.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  20. Article

309 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

92 authors at 20 institutions in 16 countries.

Krzysztof KirylukDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Yifu LiDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.ORCID 0000000270777689
Francesco Scolari1] Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Montichiari Hospital, University of Brescia, Brescia, Italy. [2] Department of Medical and Surgical Specialties, Radiological Sciences, University of Brescia, Brescia, Italy.
Simone Sanna-CherchiDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Murim Choi1] Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Miguel VerbitskyDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
David FaselDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Sneh LataDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Sindhuri PrakashDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Samantha ShapiroDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Clara FischmanDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Holly J SnyderDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Gerald AppelDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Claudia Izzi1] Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Montichiari Hospital, University of Brescia, Brescia, Italy. [2] Prenatal Diagnosis Unit, Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.
Battista Fabio ViolaDivision of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
Nadia Dallera1] Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Montichiari Hospital, University of Brescia, Brescia, Italy. [2] Department of Medical and Surgical Specialties, Radiological Sciences, University of Brescia, Brescia, Italy.
Lucia Del VecchioRenal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
Cristina BarlassinaRenal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
Erika SalviRenal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
Francesca Eleonora Bertinetto1] Immunogenetics and Biology of Transplantation, Città della Salute e della Scienza, University Hospital of Turin, Turin, Italy. [2] Medical Genetics, Department of Medical Sciences, University of Torino, Turin, Italy.
Antonio Amoroso1] Immunogenetics and Biology of Transplantation, Città della Salute e della Scienza, University Hospital of Turin, Turin, Italy. [2] Medical Genetics, Department of Medical Sciences, University of Torino, Turin, Italy.
Silvana SavoldiNephrology and Dialysis Unit, Ospedali di Cirié e Chivasso, Cirié, Turin, Italy.
Marcella RocchiettiNephrology and Dialysis Unit, Ospedali di Cirié e Chivasso, Cirié, Turin, Italy.
Alessandro AmoreNephrology, Dialysis and Transplantation Unit, Regina Margheritra Hospital, Turin, Italy.
Licia PeruzziNephrology, Dialysis and Transplantation Unit, Regina Margheritra Hospital, Turin, Italy.
Rosanna CoppoNephrology, Dialysis and Transplantation Unit, Regina Margheritra Hospital, Turin, Italy.
Maurizio SalvadoriDivision of Nephrology and Renal Transplantation, Carreggi Hospital, Florence, Italy.
Pietro Ravani1] Department of Medicine, University of Calgary, Calgary, Alberta, Canada. [2] Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
Riccardo MagistroniDivision of Nephrology Dialysis and Transplantation, Azienda Ospedaliero Universitaria Policlinico di Modena, Università di Modena e Reggio Emilia, Modena, Italy.
Gian Marco GhiggeriDivision of Nephrology, Dialysis and Transplantation, Giannina Gaslini Institute, Genova, Italy.
Gianluca CaridiDivision of Nephrology, Dialysis and Transplantation, Giannina Gaslini Institute, Genova, Italy.
Monica BodriaDivision of Nephrology, Dialysis and Transplantation, Giannina Gaslini Institute, Genova, Italy.
Francesca LuganiDivision of Nephrology, Dialysis and Transplantation, Giannina Gaslini Institute, Genova, Italy.
Landino Allegri1] Division of Nephrology, Azienda Ospedaliero Universitaria, Parma, Italy. [2] Chair of Nephrology, University of Parma, Parma, Italy.
Marco Delsante1] Division of Nephrology, Azienda Ospedaliero Universitaria, Parma, Italy. [2] Chair of Nephrology, University of Parma, Parma, Italy.
Mariarosa Maiorana1] Division of Nephrology, Azienda Ospedaliero Universitaria, Parma, Italy. [2] Chair of Nephrology, University of Parma, Parma, Italy.
Andrea Magnano1] Division of Nephrology, Azienda Ospedaliero Universitaria, Parma, Italy. [2] Chair of Nephrology, University of Parma, Parma, Italy.
Giovanni FrascaDivision of Nephrology, Dialysis and Renal Transplantation, Riuniti Hospital, Ancona, Italy.
Emanuela BoerDivision of Nephrology and Dialysis, Gorizia Hospital, Gorizia, Italy.
Giuliano BoscuttiDivision of Nephrology, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Trieste, Trieste, Italy.
Claudio PonticelliNephrology and Dialysis Unit, Humanitas Clinical and Research Center, Milan, Italy.
Renzo MignaniDivision of Nephrology and Dialysis, Infermi Hospital, Rimini, Italy.
Carmelita MarcantoniDivision of Nephrology, Cannizzaro Hospital, Catania, Italy.
Domenico Di LandroDivision of Nephrology, Cannizzaro Hospital, Catania, Italy.
Domenico SantoroChair of Nephrology, Division of Nephology and Dialysis, University of Messina, Azienda Ospedaliero-Universitaria Policlinico, Messina, Italy.
Antonello PaniDepartment of Nephrology and Dialysis, G. Brotzu Hospital, Cagliari, Italy.
Rosaria PolciNephrology and Dialysis, Hospital of Viterbo, Viterbo, Italy.
Sandro FeriozziNephrology and Dialysis, Hospital of Viterbo, Viterbo, Italy.
Silvana ChiccaDivision of Nephrology and Dialysis, Sandro Pertini Hospital, Rome, Italy.
Marco GallianiDivision of Nephrology and Dialysis, Sandro Pertini Hospital, Rome, Italy.
Maddalena GiganteDepartment of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Loreto GesualdoSection of Nephrology, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Pasquale ZamboliDepartment of Nephrology, Second University of Naples, Naples, Italy.
Giovanni Giorgio BattagliaUnità Operativa di Nefrologia e Dialisi, Ospedale di Acireale, Acireale, Italy.
Maurizio GarozzoUnità Operativa di Nefrologia e Dialisi, Ospedale di Acireale, Acireale, Italy.
Dita MaixnerováDepartment of Nephrology, 1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.
Vladimir TesarDepartment of Nephrology, 1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.
Frank Eitner1] Department of Nephrology, RWTH (Rheinisch-Westfälische Technische Hochschule) University of Aachen, Aachen, Germany. [2] Kidney Diseases Research, Bayer Pharma, Wuppertal, Germany.
Thomas RauenDepartment of Nephrology, RWTH (Rheinisch-Westfälische Technische Hochschule) University of Aachen, Aachen, Germany.
Jürgen FloegeDepartment of Nephrology, RWTH (Rheinisch-Westfälische Technische Hochschule) University of Aachen, Aachen, Germany.
Tibor Kovacs1] Nephrology Center, Medical Faculty, University of Pécs, Pécs, Hungary. [2] Second Department of Internal Medicine, Medical Faculty, University of Pécs, Pécs, Hungary.
Judit Nagy1] Nephrology Center, Medical Faculty, University of Pécs, Pécs, Hungary. [2] Second Department of Internal Medicine, Medical Faculty, University of Pécs, Pécs, Hungary.
Krzysztof MuchaDepartment of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Leszek PączekDepartment of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Marcin ZaniewKrysiewicza Children's Hospital, Poznań, Poland.
Małgorzata Mizerska-WasiakDepartment of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Maria Roszkowska-BlaimDepartment of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Krzysztof PawlaczykDepartment of Nephrology, Transplantology and Internal Medicine, Poznan Medical University, Poznan, Poland.
Daniel GaleUniversity College London Centre for Nephrology, Royal Free Hospital Pond Street, London, UK.ORCID 0000000291701579
Jonathan Barratt1] John Walls Renal Unit, University Hospitals of Leicester, Leicester, UK. [2] Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Lise ThibaudinDepartment of Nephrology, Dialysis and Renal Transplantation, University North Hospital, Saint Etienne, France.
Francois BerthouxDepartment of Nephrology, Dialysis and Renal Transplantation, University North Hospital, Saint Etienne, France.
Guillaume Canaud1] Service de Néphrologie Transplantation Adultes, Hôpital Necker-Enfants Malades, Paris, France. [2] INSERM, Institut Necker-Enfants Malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Anne BolandCentre National de Génotypage, Commissariat à l'Energie Atomique (CEA), Institut de Génomique, Evry, France.
Marie Metzger1] INSERM, Centre for Research in Epidemiology and Population Health, Villejuif, France. [2] University Paris-Sud, Villejuif, France.
Ulf PanzerIII Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Hitoshi SuzukiDivision of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.
Shin GotoDivision of Clinical Nephrology and Rheumatology, Niigata University, Niigata, Japan.
Ichiei NaritaDivision of Clinical Nephrology and Rheumatology, Niigata University, Niigata, Japan.
Yasar CaliskanDivision of Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Jingyuan XieDepartment of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ping HouRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
Nan ChenDepartment of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hong ZhangRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
Robert J Wyatt1] Division of Pediatric Nephrology, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA. [2] Children's Foundation Research Center, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
Jan NovakDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Bruce A JulianDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
John Feehally1] John Walls Renal Unit, University Hospitals of Leicester, Leicester, UK. [2] Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Benedicte Stengel1] INSERM, Centre for Research in Epidemiology and Population Health, Villejuif, France. [2] University Paris-Sud, Villejuif, France.
Daniele CusiRenal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
Richard P Lifton1] Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA.
Ali G GharaviDivision of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Columbia University · USAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITIstituto Giannina Gaslini · ITMedical University of Warsaw · PLOspedale di Parma · ITUniversity of Milan · ITOspedale Regina Margherita · ITWestfälische Hochschule · DEAzienda Sanitaria Locale Viterbo · ITCharles University · CZDepartment of Medical Sciences · RUInserm · FRNiigata University · JPOspedale Cannizzaro · ITOspedale Sandro Pertini · ITOspedale Sant'Anna · ITPeking University · CNShanghai Jiao Tong University · CNUniversity of Alabama at Birmingham · USUniversity of Leicester · GB

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S. · 2008 to 2022
$16.8M
Elucidating IgA Nephropathy through Genetic Studies of IgA1 GlycosylationR01DK082753 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GHARAVI, ALI G, NOVAK, JAN · 2009 to 2024
$8.7M
Discovery and fine mapping of susceptibility loci for IgA nephropathyR01DK095510 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GHARAVI, ALI G, LIFTON, RICHARD P · 2012 to 2016
$2.7M
Genetics of Congenital Obstructive UropathyR01DK103184 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANNA-CHERCHI, SIMONE · 2014 to 2018
$2.3M
Quantitative Genetics of Defective IgA1 Glycosylation in IgA NephropathyK23DK090207 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIRYLUK, KRZYSZTOF · 2011 to 2014
$729k
Genetic diagnosis of kidney and urinary tract malformations via copy number variaR21DK098531 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANNA-CHERCHI, SIMONE · 2013 to 2014
$440k
Population-based study of serum IgA, IgA1, and galactose-deficient IgA1 levelsR03DK099564 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIRYLUK, KRZYSZTOF · 2013 to 2014
$160k
Howard Hughes Medical InstituteMedical Research Council G1002528NCATS NIH HHS UL1 TR000142NIDDK NIH HHS K23 DK090207NIDDK NIH HHS K23DK090207NIDDK NIH HHS P30 DK079310NIDDK NIH HHS R01 DK082753NIDDK NIH HHS R01DK082753NIDDK NIH HHS R01 DK095510NIDDK NIH HHS R01DK095510NIDDK NIH HHS R01 DK103184NIDDK NIH HHS R03 DK099564NIDDK NIH HHS R03DK099564NIDDK NIH HHS R21DK09853NIDDK NIH HHS R21 DK098531
6 · The paper itself

Abstract

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of risk alleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN.

Indexed as

Age of OnsetCARD Signaling Adaptor ProteinsCD11b AntigenGenetic LociGenetic PleiotropyGenome-Wide Association StudyGlomerulonephritis, IGAHLA-D AntigensHost-Pathogen InteractionsHumansImmunityIntestinesPolymorphism, Single NucleotideProto-Oncogene Proteins c-vavCARD9 protein, humanCARD Signaling Adaptor ProteinsCD11b AntigenHLA-D AntigensITGAM protein, humanProto-Oncogene Proteins c-vavVAV3 protein, human

Identifiers

PMID25305756
PMCPMC4213311
OpenAlexW2101794801

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.