ArticleNature nanotechnology2014
Coherent anti-Stokes Raman scattering microscopy of single nanodiamonds.
Article in Nature nanotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Unveiling the complexity of nanodiamond structures.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- [Application of Raman-based technologies in the detection of urological tumors].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Intracellular Thermal Probing Using Aggregated Fluorescent Nanodiamonds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Fluorescent nanodiamonds for characterization of nonlinear microscopy systems.Photonics research · 2021Article
- Quantitative Label-Free Imaging of Lipid Domains in Single Bilayers by Hyperspectral Coherent Raman Scattering.Analytical chemistry · 2020Article
- Lipid Bilayer Thickness Measured by Quantitative DIC Reveals Phase Transitions and Effects of Substrate Hydrophilicity.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Potential Application of Upconverting Nanoparticles for Brain Photobiomodulation.Photobiomodulation, photomedicine, and laser surgery · 2019Review
- Production of Metal-Free Diamond Nanoparticles.ACS omega · 2018Article
- Cancer Immunotherapy Getting Brainy: Visualizing the Distinctive CNS Metastatic Niche to Illuminate Therapeutic Resistance.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2017Review
- Generally Applicable Transformation Protocols for Fluorescent Nanodiamond Internalization into Cells.Scientific reports · 2017Article
- Stimulated Raman scattering of polymer nanoparticles for multiplexed live-cell imaging.Chemical communications (Cambridge, England) · 2017Article
- Nanodiamonds as multi-purpose labels for microscopy.Scientific reports · 2017Article
- Inner ear barriers to nanomedicine-augmented drug delivery and imaging.Journal of otology · 2016Review
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Authors and funding
8 authors.
Funding
Abstract
Nanoparticles have attracted enormous attention for biomedical applications as optical labels, drug-delivery vehicles and contrast agents in vivo. In the quest for superior photostability and biocompatibility, nanodiamonds are considered one of the best choices due to their unique structural, chemical, mechanical and optical properties. So far, mainly fluorescent nanodiamonds have been utilized for cell imaging. However, their use is limited by the efficiency and costs in reliably producing fluorescent defect centres with stable optical properties. Here, we show that single non-fluorescing nanodiamonds exhibit strong coherent anti-Stokes Raman scattering (CARS) at the sp(3) vibrational resonance of diamond. Using correlative light and electron microscopy, the relationship between CARS signal strength and nanodiamond size is quantified. The calibrated CARS signal in turn enables the analysis of the number and size of nanodiamonds internalized in living cells in situ, which opens the exciting prospect of following complex cellular trafficking pathways quantitatively.
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