Evidence map›Paper›PMID 25305474›Full record

ReviewJournal of molecular biology2014

The microbiota, chemical symbiosis, and human disease.

Matthew R Redinbo

Abstract readReview
In one paragraph

Review in Journal of molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 60 citations in OpenAlex.

  1. Trial
  2. Review
  3. Observational
  4. The Microbiota in Cancer: A Secondary Player or a Protagonist?Current issues in molecular biology · 2024
    Review
  5. Review
  6. Review
  7. Urobiome: An outlook on the metagenome of urological diseases.Investigative and clinical urology · 2021
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Bacterial Community Interactions During Chronic Respiratory Disease.Frontiers in cellular and infection microbiology · 2020
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Matthew R RedinboDepartment of Chemistry, Department of Biochemistry and Biophysics, Department of Microbiology and Immunology, College of Arts and Sciences, Integrative Program for Biological and Genome Sciences, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA. Electronic address: redinbo@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Improving CPT-11 Efficacy Using Structural BiologyR01CA098468 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REDINBO, MATTHEW R · 2003 to 2018
$3.9M
NCI NIH HHS R01 CA098468
6 · The paper itself

Abstract

Our understanding of mammalian-microbial mutualism has expanded by combing microbial sequencing with evolving molecular and cellular methods, as well as unique model systems. Here, the recent literature linking the microbiota to diseases of three of the key mammalian mucosal epithelial compartments-nasal, lung, and gastrointestinal tract-is reviewed with a focus on new knowledge about the taxa, species, proteins, and chemistry that promote health and impact progression toward disease. The information presented is further organized by specific diseases now associated with the microbiota: Staphylococcus aureus infection and rhinosinusitis in the nasal-sinus mucosa, as well as cystic fibrosis, chronic obstructive pulmonary disorder, and asthma in the pulmonary tissues. For the vast and microbially dynamic gastrointestinal compartment, several disorders are considered, including obesity, atherosclerosis, Crohn's disease, ulcerative colitis, drug toxicity, and even autism. Our appreciation of the chemical symbiosis ongoing between human systems and the microbiota continues to grow and suggests new opportunities for modulating this symbiosis using designed interventions.

Indexed as

Host-Pathogen InteractionsMicrobiotaSymbiosisGastrointestinal DiseasesGastrointestinal TractHumansLungLung DiseasesMetabolic DiseasesNasal MucosaSinusitisepitheliaintestinelungmucosanasal sinuses

Identifiers

PMID25305474
PMCPMC4252811
OpenAlexW1992996811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.