Evidence map›Paper›PMID 25305427›Full record

ArticleJournal of affective disorders2015

Is maternal smoking during pregnancy associated with bipolar disorder in offspring?

Roshan Chudal, Alan S Brown, Mika Gissler, Auli Suominen, Andre Sourander

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The role of pre-, peri-, and postnatal risk factors in bipolar disorder and adult ADHD.Journal of neural transmission (Vienna, Austria : 1996) · 2019
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 4 countries.

Roshan ChudalDepartment of Child Psychiatry, University of Turku, Turku, Finland. Electronic address: roschu@utu.fi.
Alan S BrownDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, USA; Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, USA.
Mika GisslerDepartment of Child Psychiatry, University of Turku, Turku, Finland; Nordic School of Public Health, Gothenburg, Sweden; National Institute for Health and Welfare, Helsinki, Finland.
Auli SuominenDepartment of Child Psychiatry, University of Turku, Turku, Finland.
Andre SouranderDepartment of Child Psychiatry, University of Turku, Turku, Finland; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, USA; Department of Child Psychiatry, Turku University Hospital, Turku, Finland; Regional Centre for Child and Youth Mental Health and Child Welfare, University of Tromsø, Tromso, Norway.
University of Turku · FIColumbia University · US

Funding

Epidemiology of Prenatal Factors and Adult PsychopathologyK02MH065422 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BROWN, ALAN STEWART · 2003 to 2012
$1.2M
Medical Research Council MR/K006525/1NIMH NIH HHS 5K02-MH65422NIMH NIH HHS K02 MH065422
6 · The paper itself

Abstract

backgroundPrenatal smoking exposure affects fetal growth and development and is associated with increased risk of various neurodevelopmental disorders. Only one previous study has examined the association between maternal smoking during pregnancy and the risk of bipolar disorder (BPD).

methodsIn this nested case control study derived from all singleton live births in Finland between January 1st 1987 and December 31st 1998, we identified 724 children diagnosed and/or treated with BPD until 2008 and 1419 matched controls from four nationwide registers. Conditional logistic regression was used to examine the association between maternal smoking during pregnancy and BPD adjusting for potential confounding due to parental psychiatric history, maternal age and education level.

results18.5% of offspring were exposed to maternal smoking during pregnancy. In the unadjusted analysis, smoking during pregnancy was associated with a 1.41-fold (95% CI 1.12-1.79, P=0.004) increased risk of BPD. In the final model adjusting for potential covariates, the risk was 1.14-fold (95% CI 0.88-1.49, P=0.323). LIMITATIONS: The limitations of this study include: hospital based clinical diagnosis for case ascertainment, inclusion of early onset BPD cases, and lack of information on alcohol or other substance abuse during pregnancy.

conclusionThis study demonstrated that, in this sample, an increased risk of BPD among offspring of mothers who smoked during pregnancy is most likely due to confounding by familial background factors. Future studies including information on serological measures of smoking exposure in pregnancy e.g. cotinine are warranted to further clarify this association.

Indexed as

AdolescentAdultBipolar DisorderCase-Control StudiesCausalityChildChild, PreschoolComorbidityFemaleFinlandHumansLogistic ModelsMaleMothersPregnancyPrenatal Exposure Delayed EffectsBipolar disorderPrenatalSmoking during pregnancy

Identifiers

PMID25305427
PMCPMC4253972
OpenAlexW1969559495

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.