Trial reportJournal of diabetes science and technology2015
Time lag of glucose from intravascular to interstitial compartment in type 1 diabetes.
Trial report in Journal of diabetes science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- International Society for Pediatric and Adolescent Diabetes Clinical Practice Consensus Guidelines 2024 Diabetes Technologies: Glucose Monitoring.Hormone research in paediatrics · 2024Guideline
- Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline.Journal of diabetes science and technology · 2020Guideline
- Trial
- Trial
- Lag Time Remains with Newer Real-Time Continuous Glucose Monitoring Technology During Aerobic Exercise in Adults Living with Type 1 Diabetes.Diabetes technology & therapeutics · 2019Trial
- Evaluation of a New Noninvasive Glucose Monitoring Device by Means of Standardized Meal Experiments.Journal of diabetes science and technology · 2018Trial
- Bolusing frequency and amount impacts glucose control during hybrid closed-loop.Diabetic medicine : a journal of the British Diabetic Association · 2018Trial
- Successful Application of Closed-Loop Artificial Pancreas Therapy After Islet Autotransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Trial
- Prevalence, duration, and clinical implications of continuous glucose monitor measurement limit capping in type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Decision accuracy of simultaneously used real-time CGM versus intermittently scanned CGM around exercise in type 1 diabetes: A secondary analysis of the ULTRAFLEXI-1 study.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Performance of three simultaneously used rtCGM systems around a physically active weekend camp in adults with type 1 diabetes: A prospective lab and real-world study.Diabetes, obesity & metabolism · 2026Article
- In Vivo Evaluation of a Novel Long-Term Intravascular Implantable Continuous Blood Glucose Monitor in an Ovine Model: A Glucotrack Inc. Investigation.Journal of diabetes research · 2026Article
- A personalized and automated real-time meal detection algorithm based on continuous glucose monitoring and heart rate data for individuals with post-bariatric hypoglycemia.Frontiers in digital health · 2026Article
- Circadian influences on glycemic control in 24-hr fasts initiated at different mealtimes.Frontiers in nutrition · 2026Article
- Continuous glucose monitoring (CGM) systems in Poland, Europe, and beyond in 2025: principles, available technologies, and future perspectives.Archives of medical science : AMS · 2026Article
- The 'Designer' Artificial Pancreas: How Does Current Technology Mimic Pancreatic Physiology?Cureus · 2025Review
- Continuous glucose monitoring in adults with short bowel syndrome receiving overnight infusions of home parenteral nutrition.European journal of clinical nutrition · 2025Article
- Cyber-Physical-Human Systems in Precision Medicine: Advances in Artificial Pancreas for Treatment of Diabetes.Annual reviews in control · 2025Article
- A Passive Perspiration Inspired Wearable Platform for Continuous Glucose Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Flap Monitoring Using Interstitial Fluid Glucose Measurements.Plastic surgery (Oakville, Ont.) · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The premise of effective closed-loop insulin therapy for type 1 diabetes (T1D) relies on the accuracy of continuous interstitial fluid glucose sensing that represents the crucial afferent arm of such a system. An important determinant of sensor accuracy is the physiological time lag of glucose transport from the vascular to the interstitial space. The purpose of current studies was to determine the physiological time lag of glucose transport from the vascular to the abdominal subcutaneous interstitial space in T1D. Four microdialysis catheters were inserted into the abdominal subcutaneous space in 6 T1D subjects under overnight fasted conditions. Plasma glucose was maintained at 113.7 ± 6.3 mg/dl using a continuous intravenous insulin infusion. After sequential intravenous bolus administrations of glucose isotopes, timed plasma and interstitial fluid samples were collected chronologically and analyzed for tracer enrichments. We observed a median (range) time lag of tracer appearance (time to detection) into the interstitial space after intravenous bolus of 6.8 (4.8-9.8) minutes, with all participants having detectable values by 9.8 minutes. We conclude that in the overnight fasted state in T1D adults, the delay of glucose appearance from the vascular to the interstitial space is less than 10 minutes, thereby implying that this minimal physiological time lag should not be a major impediment to the development of an effective closed-loop control system for T1D.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.