ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2015
Acoustic startle in alcohol-naïve male rats predicts subsequent voluntary alcohol intake and alcohol preference.
Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Assessing negative affect in mice during abstinence from alcohol drinking: Limitations and future challenges.Alcohol (Fayetteville, N.Y.) · 2022Review
- Heavy marijuana use but not deprivation is associated with increased stressor reactivity.Journal of abnormal psychology · 2018Article
- Increased startle potentiation to unpredictable stressors in alcohol dependence: Possible stress neuroadaptation in humans.Journal of abnormal psychology · 2017Article
- Probing for Neuroadaptations to Unpredictable Stressors in Addiction: Translational Methods and Emerging Evidence.Journal of studies on alcohol and drugs · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
aimsAcoustic startle response in rats is used to model sensorimotor reactivity. The aim of the study was to determine whether acoustic startle response in alcohol-naïve rats predicts subsequent increased voluntary alcohol drinking or alcohol preference.
methodsStartle responses to 90, 95 and 100 decibel (dB) white noise stimuli presented in counterbalanced semi-randomized order were tested in alcohol-naïve young adult male Wistar rats before voluntary alcohol intake was established with an intermittent alcohol access (IAA) model.
resultsStartle amplitude in response to 95 or 100 dB stimuli was positively correlated with subsequent alcohol intake and alcohol preference following 3 months of IAA. Rats with high (median split) pre-IAA startle amplitude in response to 95 or 100 dB stimuli developed increased alcohol intake as well as increased alcohol preference following 3 months of IAA, relative to rats with low pre-IAA startle amplitude.
conclusionStartle response to moderate acoustic stimuli can be a predictive index of vulnerability to developing increased alcohol drinking.
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