ArticleThe American journal of medicine2015
Long-term adherence to healthy dietary guidelines and chronic inflammation in the prospective Whitehall II study.
Article in The American journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- A systematic review and meta-analysis of loss-of-control eating in relation to cardiometabolic health components and inflammatory markers.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024Pooled it
- Dietary patterns and associations with biomarkers of inflammation in adults: a systematic review of observational studies.Nutrition journal · 2021Pooled it
- Lifestyle Modification for the Management of Psoriatic Arthritis.American journal of lifestyle medicine · 2026Review
- Metabolomic signatures reveal an association between healthy dietary patterns and brain aging.The journal of nutrition, health & aging · 2026Article
- Metformin attenuates fructose-induced pulmonary fibrosis, possibly through the involvement of the TRPC6 channel.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- From Food to Mood: Psychological and Psychiatric Impact of Diet in Bipolar Disorder.Nutrients · 2025Review
- An unbiased, sustainable, evidence-informed Universal Food Guide: a timely template for national food guides.Nutrition journal · 2024Review
- Managing the Patient with Psoriasis and Metabolic Comorbidities.American journal of clinical dermatology · 2024Review
- Academy of Plant-based Physical Therapy: overdue to address a nutrition crisis with a transformative population approach.Journal of physical therapy science · 2023Review
- Interrogating Components of 2 Diet Quality Indices in Pregnancy using a Supervised Statistical Mixtures Approach.The American journal of clinical nutrition · 2023Article
- Adherence to Healthy Lifestyle Prior to Infection and Risk of Post-COVID-19 Condition.JAMA internal medicine · 2023Article
- Adherence to Healthy and Sustainable Dietary Patterns and Long-Term Chronic Inflammation: Data from the EPIC-Potsdam Cohort.The journal of nutrition, health & aging · 2023Article
- Diet Quality and Health in Older Americans.Nutrients · 2022Article
- Immuno-modulation with lifestyle behaviour change to reduce SARS-CoV-2 susceptibility and COVID-19 severity: goals consistent with contemporary physiotherapy practice.Physiotherapy · 2022Review
- Long-term diet quality and its change in relation to late-life subjective cognitive decline.The American journal of clinical nutrition · 2022Article
- Associations Between Dietary Patterns and Neuroimaging Markers: A Systematic Review.Frontiers in nutrition · 2022Review
- A Dietary Inflammatory Index and associations with C-reactive protein in a general adult population.European journal of nutrition · 2021Article
- Diet supporting therapy for inflammatory bowel diseases.European journal of nutrition · 2021Review
- Food and nutrient intake and diet quality among older Americans.Public health nutrition · 2021Article
- Pre-pregnancy diet quality and its association with offspring behavioral problems.European journal of nutrition · 2021Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundInflammation plays an important role in the cause of cardiovascular diseases and may contribute to the association linking an unhealthy diet to chronic age-related diseases. However, to date the long-term associations between diet and inflammation have been poorly described. Our aim was to assess the extent to which adherence to a healthy diet and dietary improvements over a 6-year exposure period prevented subsequent chronic inflammation over a 5-year follow-up in a large British population of men and women.
methodsData were drawn from 4600 adults (mean ± standard deviation, age 49.6 ± 6.1 years, 28% were women) from the prospective Whitehall cohort II study. Adherence to a healthy diet was measured using Alternative Healthy Eating Index (AHEI) scores in 1991-1993 (50.7 ± 11.9 points) and 1997-1999 (51.6 ± 12.4 points). Chronic inflammation, defined as average levels of serum interleukin-6 from 2 measures 5 years apart, was assessed in 1997-1999 and 2002-2004.
resultsAfter adjustment for sociodemographic factors, health behaviors, and health status, participants who maintained a high AHEI score (ie, a healthy diet, n = 1736, 37.7%) and those who improved this score over time (n = 681, 14.8%) showed significantly lower mean levels of interleukin-6 (1.84 pg/mL, 95% confidence interval [CI], 1.71-1.98 and 1.84 pg/mL, 95% CI, 1.70-1.99, respectively) than those who had a low AHEI score (n = 1594, 34.6%) over the 6-year exposure period (2.01 pg/mL, 95% CI, 1.87-2.17).
conclusionsThese data suggest that maintaining and improving adherence to healthy dietary recommendations may reduce the risk of long-term inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.