Evidence map›Paper›PMID 25305179›Full record

Trial reportAmerican journal of physiology. Heart and circulatory physiology2014

Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure.

Ligia M Antunes-Correa, Thais S Nobre, Raphaela V Groehs, Maria Janieire N N Alves, Tiago Fernandes, Gisele K Couto, Maria Urbana P B Rondon, Patricia Oliveira, Marta Lima, Wilson Mathias and 7 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 7 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 7 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Ligia M Antunes-CorreaHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Thais S NobreHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Raphaela V GroehsHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Maria Janieire N N AlvesHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Tiago FernandesSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil;
Gisele K CoutoInstitute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil;
Maria Urbana P B RondonSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil;
Patricia OliveiraHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Marta LimaHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Wilson MathiasHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Patricia C BrumSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil;
Charles MadyHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Dirceu R AlmeidaDepartment of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil; and.
Luciana V RossoniInstitute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil;
Edilamar M OliveiraSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil;
Holly R MiddlekauffDepartament of Medicine (Cardiology) and Physiology, Geffen School of Medicine at University of California, Los Angeles, California.
Carlos E NegraoHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil; School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil; cndnegrao@incor.usp.br.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have demonstrated that muscle mechanoreflex and metaboreflex controls are altered in heart failure (HF), which seems to be due to changes in cyclooxygenase (COX) pathway and changes in receptors on afferent neurons, including transient receptor potential vanilloid type-1 (TRPV1) and cannabinoid receptor type-1 (CB1). The purpose of the present study was to test the hypotheses: 1) exercise training (ET) alters the muscle metaboreflex and mechanoreflex control of muscle sympathetic nerve activity (MSNA) in HF patients. 2) The alteration in metaboreflex control is accompanied by increased expression of TRPV1 and CB1 receptors in skeletal muscle. 3) The alteration in mechanoreflex control is accompanied by COX-2 pathway in skeletal muscle. Thirty-four consecutive HF patients with ejection fractions <40% were randomized to untrained (n = 17; 54 ± 2 yr) or exercise-trained (n = 17; 56 ± 2 yr) groups. MSNA was recorded by microneurography. Mechanoreceptors were activated by passive exercise and metaboreceptors by postexercise circulatory arrest (PECA). COX-2 pathway, TRPV1, and CB1 receptors were measured in muscle biopsies. Following ET, resting MSNA was decreased compared with untrained group. During PECA (metaboreflex), MSNA responses were increased, which was accompanied by the expression of TRPV1 and CB1 receptors. During passive exercise (mechanoreflex), MSNA responses were decreased, which was accompanied by decreased expression of COX-2, prostaglandin-E2 receptor-4, and thromboxane-A2 receptor and by decreased in muscle inflammation, as indicated by increased miRNA-146 levels and the stable NF-κB/IκB-α ratio. In conclusion, ET alters muscle metaboreflex and mechanoreflex control of MSNA in HF patients. This alteration with ET is accompanied by alteration in TRPV1 and CB1 expression and COX-2 pathway and inflammation in skeletal muscle.

Indexed as

Exercise TherapyAdultAgedChronic DiseaseCyclooxygenase 2Exercise TestFemaleHeart FailureHumansMaleMiddle AgedMuscle, SkeletalReceptor, Cannabinoid, CB1ReflexSignal TransductionStroke VolumeCyclooxygenase 2Receptor, Cannabinoid, CB1TRPV1 protein, humanTRPV Cation Channelsexercise trainingheart failuremechanoreflexmetaboreflexmuscle sympathetic nervous system

Identifiers

PMID25305179
PMCPMC4255006
OpenAlexW2160269379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.