ArticleOsteoarthritis and cartilage2014
Pain trajectory groups in persons with, or at high risk of, knee osteoarthritis: findings from the Knee Clinical Assessment Study and the Osteoarthritis Initiative.
Article in Osteoarthritis and cartilage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis.BMC musculoskeletal disorders · 2018Pooled it
- SPOT: An Early Detection Tool for Predicting Pain Trajectories Following Intra-Articular Injections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Trial
- Five-year follow-up of patients with knee osteoarthritis not eligible for total knee replacement: results from a randomised trial.BMJ open · 2022Trial
- Short-Term Recovery Trajectories of Acute Flares in Knee Pain: A UK-Netherlands Multicenter Prospective Cohort Analysis.Arthritis care & research · 2020Trial
- Association of baseline MRI-defined structural features with knee symptom trajectories over nine years: Data from the osteoarthritis initiative (OAI).Osteoarthritis imaging · 2026Article
- Beyond the algorithms: Challenges in predicting knee osteoarthritis pain from a machine learning point of view.Osteoarthritis imaging · 2026Article
- Pragmatic evaluation of prescription glucosamine sulfate (pGS) in knee osteoarthritis: insights from a Filipino cohort.Frontiers in medicine · 2026Article
- Preoperative Clinical Phenotyping for Individualised Rehabilitation in End-Stage Knee Osteoarthritis.Journal of functional morphology and kinesiology · 2025Article
- MonitOring the health trajectory of patients with kNee osteoarthritis referred for orthopaedic opinion: Protocol for the MOTION parallel cohort-implementation study.Osteoarthritis and cartilage open · 2025Article
- Expression of thrombospondin-4 in the infrapatellar fat pad and synovial fluid - potential contribution to osteoarthritis pain.Arthritis research & therapy · 2025Article
- Association between widespread pain and psychosocial factors in people with knee osteoarthritis: a cross-sectional study of patients from primary care in Denmark.Physiotherapy theory and practice · 2025Article
- Advances and Challenges in the Pursuit of Disease-Modifying Osteoarthritis Drugs: A Review of 2010-2024 Clinical Trials.Biomedicines · 2025Review
- Current and future advances in practice: practical management of hand osteoarthritis.Rheumatology advances in practice · 2025Review
- Measurement of Pain Frequency Associated With Knee Osteoarthritis: Future Directions.The journal of pain · 2024Article
- The usefulness of ultrasound in predicting outcomes in patients with shoulder pain: a prospective observational study.Rheumatology (Oxford, England) · 2024Observational
- Identifying Weekly Trajectories of Pain Severity Using Daily Data From an mHealth Study: Cluster Analysis.JMIR mHealth and uHealth · 2024Article
- Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA).BMC musculoskeletal disorders · 2024Article
- Trajectories and Predictors of Weight-Bearing and Non-Weight-Bearing Pain in Knee Osteoarthritis: A 9-Year Follow-Up Study.Journal of pain research · 2024Article
- Frailty predicts knee pain trajectory over 9 years: results from the Osteoarthritis Initiative.Pain medicine (Malden, Mass.) · 2023Article
- The Natural History of Knee Osteoarthritis Pain Experience and Risk Profiles.The journal of pain · 2023Observational
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveThe authors aimed to characterize distinct trajectories of knee pain in adults who had, or were at high risk of, knee osteoarthritis using data from two population-based cohorts.
methodLatent class growth analysis was applied to measures of knee pain severity on activity obtained at 18-month intervals for up to 6 years between 2002 and 2009 from symptomatic participants aged over 50 years in the Knee Clinical Assessment Study (CAS-K) in the United Kingdom. The optimum latent class growth model from CAS-K was then tested for reproducibility in a matched sample of participants from the Osteoarthritis Initiative (OAI) in the United States.
resultsA 5-class linear model produced interpretable trajectories in CAS-K with reasonable goodness of fit and which were labelled "Mild, non-progressive" (N = 201, 35%), "Progressive" (N = 162, 28%), "Moderate" (N = 124, 22%) "Improving" (N = 68, 12%), and "Severe, non-improving" (N = 15, 3%). We were able to reproduce "Mild, non-progressive", "Moderate", and "Severe, non-improving" classes in the matched sample of participants from the OAI, however, absence of a "Progressive" class and instability of the "Improving" classes in the OAI was observed.
conclusionsOur findings strengthen the grounds for moving beyond a simple stereotype of osteoarthritis as "slowly progressive". Mild, non-progressive or improving symptom trajectories, although difficult to reproduce, can nevertheless represent a genuinely favourable prognosis for a sizeable minority.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.