Evidence map›Paper›PMID 25305053›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2014

Genetic modification of the effect of maternal household air pollution exposure on birth weight in Guatemalan newborns.

Lisa M Thompson, Paul Yousefi, Reneé Peñaloza, John Balmes, Nina Holland

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lisa M ThompsonFamily Health Care Nursing, School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0606, San Francisco, CA 94143-0606, United States. Electronic address: lisa.thompson@nursing.ucsf.edu.
Paul YousefiEnvironmental Health Sciences, School of Public Health, University of California, Berkeley, 50 University Hall, Berkeley, CA 94720-7360, United States.
Reneé PeñalozaFamily Health Care Nursing, School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0606, San Francisco, CA 94143-0606, United States.
John BalmesEnvironmental Health Sciences, School of Public Health, University of California, Berkeley, 50 University Hall, Berkeley, CA 94720-7360, United States; Division of Occupational and Environmental Medicine, Department of Medicine, University of California, San Francisco, United States.
Nina HollandEnvironmental Health Sciences, School of Public Health, University of California, Berkeley, 50 University Hall, Berkeley, CA 94720-7360, United States.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
INDOOR AIR POLLUTION AND CHILD ARI: A RANDOMIZED TRIALR01ES010178 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, KIRK R · 2001 to 2009
$4.5M
NCATS NIH HHS KL2 TR000143NCRR NIH HHS KL2 RR024130NCRR NIH HHS KL2RR024130NIEHS NIH HHS 2R01ES010178NIEHS NIH HHS R01 ES010178NIMHD NIH HHS L60 MD003455
6 · The paper itself

Abstract

Low birth weight is associated with exposure to air pollution during pregnancy. The purpose of this study was to evaluate whether null polymorphisms of Glutathione S-transferases (GSTs), specifically GSTM1 and GSTT1 genes in infants or mothers, modify the association between high exposures to household air pollution (HAP) from cooking fires and birth weight. Pregnant women in rural Guatemala were randomized to receive a chimney stove or continue to use open fires for cooking. Newborns were measured within 48 h of birth. 132 mother-infant pairs provided infant genotypes (n=130) and/or maternal genotypes (n=116). Maternal null GSTM1 was associated with a 144 g (95% CI, -291, 1) and combined maternal/infant null GSTT1 was associated with a 155 g (95% CI, -303, -8) decrease in birth weight. Although there was a trend toward higher birth weights with increasing number of expressed GST genes, the effect modification by chimney stove use was not demonstrated.

Indexed as

Birth WeightAir PollutionFemaleGlutathione TransferaseHumansInfant, NewbornMaternal ExposurePregnancyglutathione S-transferase T1Glutathione TransferaseGene–environment interactionGenetic susceptibilityGlutathione S-transferaseLow birth weightRESPIRE/CRECER studiesWoodsmoke

Identifiers

PMID25305053
PMCPMC4261074
OpenAlexW1970626628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.