Evidence map›Paper›PMID 25304688›Full record

ReviewJournal of translational medicine2014

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods.

Marialaura Madrigal, Kosagisharaf S Rao, Neil H Riordan

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 346 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
346citing papers in PubMed, 4 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05093725 unknown statusnot on this mapstarted 2021, after this paper: background citation

CD49 in Optimization The Cologenicity of Mesenchymal Stem Cell Culture Passage

TypeobservationalSponsorSohag UniversityRan2021 to 2022Enrolled10ConditionsUmbilical Cord of Normal LaborArmsflow cytomery
NCT05204329 early_phase1completednot on this mapstarted 2024, after this paper: background citation

Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2024 to 2024Enrolled9ConditionsMesenchymal Stromal Cells, Cornea, Corneal Defect, Corneal Epithelium DefectArmsMSC Secretome Eye Drops
3 · Its place in the literature

Who cites it

346 citing papers in PubMed, 4 syntheses or guidelines pooled it, 608 citations in OpenAlex.

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286 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Marialaura MadrigalDepartment of Biotechnology, Acharya Nagarjuna University, Guntur, India. marialauramadrigal@medistemresearch.com.
Kosagisharaf S RaoINDICASAT-AIP, City of Knowledge, Republic of Panama. jrao@indicasat.org.pa.
Neil H RiordanMediStem Panama Inc., City of Knowledge, Republic of Panama. nhriordan@gmail.com.
Acharya Nagarjuna University · INCity of Knowledge · PAInstituto de Investigaciones Científicas y Servicios de Alta Tecnología · PA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action, evidence is mounting that the secretions of the cells are responsible for their therapeutic effects. These secretions include molecules and extracellular vesicles that have both local and distant effects. This review summarizes the up- and down-regulation of MSC anti-inflammatory, immune modulating, anti-tumor, and regenerative secretions resulting from different stimuli including: a) hypoxia, which increases the production of growth factors and anti-inflammatory molecules; b) pro-inflammatory stimuli that induce the secretion of immune modulating and anti-inflammatory factors; and c) 3 dimensional growth which up regulates the production of anti-cancer factors and anti-inflammatory molecules compared to monolayer culture. Finally we review in detail the most important factors present in conditioned medium of MSC that can be considered protagonists of MSC physiological effects including HGF, TGF-b, VEGF, TSG-6, PGE2 and galectins 1, and 9. We conclude that there is potential for the development of acellular therapeutic interventions for autoimmune, inflammatory, and malignant diseases and tissue regeneration from cellular secretions derived from MSCs cultured under the appropriate conditions.

Indexed as

Mesenchymal Stem Cell TransplantationCell Culture TechniquesExosomesHumansIntercellular Signaling Peptides and ProteinsMesenchymal Stem CellsIntercellular Signaling Peptides and Proteins

Identifiers

PMID25304688
PMCPMC4197270
OpenAlexW2109127788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.