Evidence map›Paper›PMID 25304339›Full record

ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2014

Mouse allergen exposure and decreased risk of allergic rhinitis in school-aged children.

Tammy S Jacobs, Erick Forno, John M Brehm, Edna Acosta-Pérez, Yueh-Ying Han, Joshua Blatter, Peter Thorne, Nervana Metwali, Angel Colón-Semidey, María Alvarez and 2 more

Open access · greenAbstract read
In one paragraph

Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Bedroom Allergen Exposure Beyond House Dust Mites.Current allergy and asthma reports · 2018
    Review
  2. Allergic sensitization and objective measures of sleep in urban school-aged children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017
    Article
  3. Review
  4. Mouse Sensitivity is an Independent Risk Factor for Rhinitis in Children with Asthma.The journal of allergy and clinical immunology. In practice
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Tammy S JacobsDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, Pennsylvania.
Erick FornoDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, Pennsylvania.
John M BrehmDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, Pennsylvania.
Edna Acosta-PérezBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Yueh-Ying HanDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, Pennsylvania.
Joshua BlatterDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, Pennsylvania.
Peter ThorneDepartment of Occupational and Environmental Health, University of Iowa College of Public Health, University of Iowa, Iowa City, Iowa.
Nervana MetwaliDepartment of Occupational and Environmental Health, University of Iowa College of Public Health, University of Iowa, Iowa City, Iowa.
Angel Colón-SemideyBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
María AlvarezBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Glorisa CaninoBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: juan.celedon@chp.edu.
University of Pittsburgh · USUniversity of Puerto Rico System · PRUniversity of Iowa · US

Funding

Molecular Basis of Pediatric DiseaseK12HD052892 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TERENCE S. DERMODY · 2007 to 2026
$6.5M
Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8M
Genes, Home Allergens and Asthma Puerto Rican ChildrenR01HL079966 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2006 to 2010
$3.8M
NHLBI NIH HHS HL079966NHLBI NIH HHS HL117191NHLBI NIH HHS R01 HL079966NHLBI NIH HHS R01 HL117191NICHD NIH HHS HD052892NICHD NIH HHS K12 HD052892
6 · The paper itself

Abstract

backgroundLittle is known about exposure to mouse allergen (Mus m 1) and allergic rhinitis (AR).

objectiveTo evaluate the association between mouse allergen exposure and AR in children.

methodsWe examined the relation between mouse allergen level in house dust and AR in 511 children aged 6 to 14 years in San Juan, Puerto Rico. Study participants were chosen from randomly selected households using a multistage probability sample design. The study protocol included questionnaires, allergy skin testing, and collection of blood and dust samples. AR was defined as current rhinitis symptoms and skin test reactivity to at least one allergen.

resultsIn the multivariate analyses, mouse allergen level was associated with a 25% decreased odds of AR in participating children (95% confidence interval, 0.62-0.92). Although endotoxin and mouse allergen levels were significantly correlated (r = 0.184, P < .001), the observed inverse association between Mus m 1 and AR was not explained by levels of endotoxin or other markers of microbial or fungal exposure (peptidoglycan and glucan).

conclusionMouse allergen exposure is associated with decreased odds of AR in Puerto Rican school-aged children.

Indexed as

Air Pollution, IndoorAdolescentAllergensAnimalsAsthmaChildDustEndotoxinsFemaleHumansMaleMiceOdds RatioPuerto RicoRhinitis, AllergicSkin TestsAllergensDustEndotoxinsMus m 1 allergen, Mus musculus

Identifiers

PMID25304339
PMCPMC4256145
OpenAlexW2059257217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.