Evidence map›Paper›PMID 25304131›Full record

ArticleBiological research for nursing2015

Associations between cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression in patients prior to breast cancer surgery.

Sy-Huey Doong, Anand Dhruva, Laura B Dunn, Claudia West, Steven M Paul, Bruce A Cooper, Charles Elboim, Gary Abrams, John D Merriman, Dale J Langford and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research for nursing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 4 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Genetic Contributions of Inflammation to Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Pooled it
  5. Trial
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  8. Trial
  9. Article
  10. Article
  11. Article
  12. Latent profile analysis for assessing symptom clusters in women with breast cancer.Journal of cancer survivorship : research and practice · 2026
    Article
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  14. Review
  15. Article
  16. Article
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Sy-Huey DoongSchools of Nursing, University of California, San Francisco, CA, USA.
Anand DhruvaSchool of Medicine, University of California, San Francisco, CA, USA.
Laura B DunnSchool of Medicine, University of California, San Francisco, CA, USA.
Claudia WestSchools of Nursing, University of California, San Francisco, CA, USA.
Steven M PaulSchools of Nursing, University of California, San Francisco, CA, USA.
Bruce A CooperSchools of Nursing, University of California, San Francisco, CA, USA.
Charles ElboimRedwood Regional Medical Group, Santa Rosa, CA, USA.
Gary AbramsSchool of Medicine, University of California, San Francisco, CA, USA.
John D MerrimanSchools of Nursing, University of California, San Francisco, CA, USA.
Dale J LangfordSchools of Nursing, University of California, San Francisco, CA, USA.
Heather LeutwylerSchools of Nursing, University of California, San Francisco, CA, USA.
Christina BaggottSchools of Nursing, University of California, San Francisco, CA, USA.
Kord KoberSchools of Nursing, University of California, San Francisco, CA, USA.
Bradley E AouizeratSchools of Nursing, University of California, San Francisco, CA, USA Institute for Human Genetics, University of California, San Francisco, CA, USA.
Christine MiaskowskiSchools of Nursing, University of California, San Francisco, CA, USA chris.miaskowski@nursing.ucsf.edu.
University of California, San Francisco · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Symptom Management After Breast Cancer SurgeryR01CA107091 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2003 to 2008
$4.5M
Long-term Arm Morbidity Following Breast Cancer TreatmentR01CA118658 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2006 to 2010
$3.5M
A Whole Systems Approach to the Study of Ayurveda for Cancer SurvivorshipK23AT005340 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DHRUVA, ANAND · 2009 to 2013
$635k
Advancing the Science of Symptom Management in Oncology PatientsK05CA168960 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2013 to 2017
$453k
Identification of Genetic Markers Associated With Attentional FatigueF31NR012604 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MERRIMAN, JOHN D. · 2010 to 2013
$95k
NCCIH NIH HHS K23 AT005340NCI NIH HHS CA107091NCI NIH HHS CA118658NCI NIH HHS CA168960NCI NIH HHS K05 CA168960NCI NIH HHS R01 CA107091NCI NIH HHS R01 CA118658NCRR NIH HHS RR624130NCRR NIH HHS UL1 RR024131NINR NIH HHS F31 NR012604
6 · The paper itself

Abstract

Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in oncology patients. This symptom cluster is often attributed to the release of proinflammatory cytokines. The purposes of this study were to determine whether distinct latent classes of patients with breast cancer (n = 398) could be identified based on their experience with this symptom cluster, whether patients in these latent classes differed on demographic and clinical characteristics and whether variations in cytokine genes were associated with latent class membership. Three distinct latent classes were identified: "all low" (61.0%), "low pain and high fatigue" (31.6%), "all high" (7.1%). Compared to patients in the all low class, patients in the all high class were significantly younger, had less education, were more likely to be non-White, had a lower annual income, were more likely to live alone, had a lower functional status, had a higher comorbidity score, and had more advanced disease. Significant associations were found between interleukin 6 (IL6) rs2069845, IL13 rs1295686, and tumor necrosis factor alpha rs18800610 and latent class membership. Findings suggest that variations in pro- and anti-inflammatory cytokine genes are associated with this symptom cluster in breast cancer patients.

Indexed as

SyndromeBreast NeoplasmsCytokinesDepressionFatigueFemaleGenotypeHumansInterleukin-6Middle AgedPainPolymorphism, Single NucleotideSleep Wake DisordersSocioeconomic FactorsTumor Necrosis Factor-alphaCytokinesInterleukin-6Tumor Necrosis Factor-alphacandidate genescytokinesdepressionfatigueinterleukinpainsleep disturbancesymptom clustertumor necrosis factor alpha

Identifiers

PMID25304131
PMCPMC5486211
OpenAlexW2113422873

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.