Evidence map›Paper›PMID 25304049›Full record

ArticleThe International journal on drug policy2015

Geographic variability in HIV and injection drug use in Ukraine: implications for integration and expansion of drug treatment and HIV care.

Nickolas Zaller, Alonya Mazhnaya, Sarah Larney, Zahed Islam, Alyona Shost, Tatiana Prokhorova, Natasha Rybak, Timothy Flanigan

Abstract read
In one paragraph

Article in The International journal on drug policy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

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  16. A Phylogenetic Analysis of Human Immunodeficiency Virus Type 1 Sequences in Kiev: Findings Among Key Populations.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Nickolas ZallerThe Miriam Hospital, Providence, RI, United States; Brown Medical School, Providence, RI, United States. Electronic address: NDZaller@uams.edu.
Alonya MazhnayaThe International HIV/AIDS Alliance, Kiev, Ukraine.
Sarah LarneyNational Drug and Alcohol Research Centre, University of New South Wales, Australia.
Zahed IslamThe International HIV/AIDS Alliance, Kiev, Ukraine.
Alyona ShostThe International HIV/AIDS Alliance, Kiev, Ukraine.
Tatiana ProkhorovaThe International HIV/AIDS Alliance, Kiev, Ukraine.
Natasha RybakThe Miriam Hospital, Providence, RI, United States; Brown Medical School, Providence, RI, United States.
Timothy FlaniganThe Miriam Hospital, Providence, RI, United States; Brown Medical School, Providence, RI, United States.
Alliance for Public Health · UABrown University · USProvidence College · USUNSW Sydney · AU

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
NIAID NIH HHS P30 AI042853NIAID NIH HHS P30-AI042853
6 · The paper itself

Abstract

backgroundUkraine has the highest HIV burden of any European country with much of the current HIV epidemic concentrated among people who inject drugs (PWIDs) and their sexual partners. Opiate substitution therapy (OST) is limited in Ukraine and expansion of OST is urgently needed to help stem the tide of the HIV epidemic.

methodsWe accessed publicly available data in Ukraine in order to explore geographic variability with respect to prevalence of HIV, PWIDs and OST programmes.

resultsThe regions of Ukraine with the largest number of opioid dependent persons (the south and eastern portions of the country) correspond to the regions with the highest HIV prevalence and HIV incidence. The number of opioid PWIDs per 100,000 population as well as the number of all OST treatment slots per 100,000 varied significantly across the three HIV prevalence categories. Overall, the proportion of individuals receiving either methadone maintenance therapy (MMT) or buprenorphine maintenance therapy (BMT) was quite low: average across categories: 7.3% and 0.4%, respectively. Additionally, less than half of OST patients receiving MMT or BMT were HIV positive patients.

conclusionThere is significant geographic variability in both numbers of HIV positive individuals and numbers of PWIDs across Ukraine, however, there may be a more concentrated epidemic among PWIDs in many regions of the country. Scale up of addiction treatment for PWID, especially OST, can have a significant impact on preventing injection related morbidity, such as HIV and HCV infection. Ukraine can learn from the mistakes other nations have made in denying critical treatment opportunities to PWID.

Indexed as

AdultBuprenorphineFemaleHIV InfectionsHumansMaleMethadoneOpiate Substitution TreatmentPrevalenceSexual PartnersSubstance Abuse, IntravenousUkraineBuprenorphineMethadoneHIVOpiate substitution therapy (OST)People who inject drugs (PWID)Ukraine

Identifiers

PMID25304049
PMCPMC4465255
OpenAlexW2025430685

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.