ArticleEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2015
Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma.
Article in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
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54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Efficacy of ColonFlag as a Complete Blood Count-Based Machine Learning Algorithm for Early Detection of Colorectal Cancer: A Systematic Review.Iranian journal of medical sciences · 2024Pooled it
- Prognostic value of neutrophil-to-lymphocyte ratio for patients with triple-negative breast cancer: A meta-analysis.Medicine · 2022Pooled it
- Anemia and associated factors among women with cancer patients in Ethiopia: A systematic review and meta-analysis.Women's health (London, England)Pooled it
- The predictive value of complete blood count and the systemic immune-inflammation index (SII) for diagnosing malignancy in patients undergoing colonoscopy.BMC primary care · 2026Article
- Systemic inflammatory biomarkers (NLR, SII, PNI and FPR) combined with CEA for predicting advanced colorectal neoplasms: development and temporal validation of a machine learning model.Frontiers in oncology · 2026Article
- Preoperative blood neutrophil-to-lymphocyte ratio, hematocrit and fibrinogen predict prognosis in colorectal cancer.Biomarkers in medicine · 2025Article
- Review
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- The unexpected effect of parathyroid adenoma on inflammation.Updates in surgery · 2024Article
- Development and validation of a web-based predictive model for preoperative diagnosis of localized colorectal cancer and colorectal adenoma.Frontiers in oncology · 2023Article
- Association between Hematological Indicesand Disease Activity in Patients with Rheumatoid Arthritis Treated with Janus Kinase Inhibitors for 24 Weeks.Medicina (Kaunas, Lithuania) · 2022Article
- Diagnostic Value of Carcinoembryonic Antigen Combined with Multi-Inflammatory Cell Ratios in Colorectal Cancer.Disease markers · 2022Article
- Blood-Cell-Based Inflammatory Markers as a Useful Tool for Early Diagnosis in Colorectal Cancer.Frontiers in medicine · 2022Article
- Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3Disease markers · 2022Article
- Development and Validation of a New Multiparametric Random Survival Forest Predictive Model for Breast Cancer Recurrence with a Potential Benefit to Individual Outcomes.Cancer management and research · 2022Article
- The evaluation of the association between the prevalence and patterns of computed tomography findings of cryptogenic organizing pneumonia, and neutrophil/lymphocyte and platelet/lymphocyte ratios.Chinese journal of academic radiology · 2022Article
- Blood Count Parameters as Inflammation Indicators in Children and Adolescents Diagnosed with Depressive Disorder.Psychiatry and clinical psychopharmacology · 2021Article
- Review
- Platelets as messengers of early-stage cancer.Cancer metastasis reviews · 2021Review
- Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer Therapies.Frontiers in oncology · 2021Review
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10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is the third most common cause of cancer-related death in Europe. The aim of the present study was to elucidate the efficiency of the neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and the mean platelet volume (MPV) as tools for the preoperative diagnosis of CRC and their usefulness in the follow-up of CRC. A total of 144 CRC patients, as diagnosed by colonoscopy, and 143 age-matched and sex-matched healthy participants were included in the study. Medical records were used to compare preoperative and postoperative data including hemoglobin levels, platelet counts, MPV, NLR, and PLR. NLR, PLR, and MPV were significantly higher in CRC patients preoperatively, compared with healthy participants. Receiver-operating characteristic curve analysis suggested 2.02 as the cutoff value for NLR [area under the curve (AUC): 0.921, sensitivity: 86%, specificity: 84%], 135 as the cutoff value for PLR, (AUC: 0.853, sensitivity: 70%, specificity: 90%) and 8.25 fl as the cutoff value for MPV (AUC: 0.717, sensitivity: 54%, specificity: 76%). Subgroup analysis showed that NLR, PLR, and MPV levels were also significantly higher in nonanemic CRC patients compared with the control group, which is of great theoretical and clinical value for the early detection of CRC. Surgical tumor resection resulted in a significant decrease in NLR, PLR, and MPV. Our results suggest that NLR, PLR, and MPV may be used as easily available additional biomarkers for CRC in screening the general population, as well as in postoperative follow-up.
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