Evidence map›Paper›PMID 25303914›Full record

ArticleSurgical endoscopy2015

Clinical applications of indocyanine green (ICG) enhanced fluorescence in laparoscopic surgery.

Luigi Boni, Giulia David, Alberto Mangano, Gianlorenzo Dionigi, Stefano Rausei, Sebastiano Spampatti, Elisa Cassinotti, Abe Fingerhut

5 registry-linked trialsOpen access · hybridAbstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 243 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
243citing papers in PubMed, 8 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02626091 nacompletednot on this mapstarted 2016, after this paper: background citation

Perfusion Evaluation by Real-time Fluorescence-based Enhanced Reality of Anastomosis

TypeinterventionalSponsorIHU StrasbourgRan2016 to 2018Enrolled27ConditionsSigmoid Diverticulosis, Sigmoid Diverticulitis, Colorectal MalignancyArmsLeft-sided colonic resection
NCT03024892 naunknown statusnot on this map

Intra-gallbladder or Systemic Indocyanide Green Injection Facilitate Cholecystectomy in Acute Cholecystitis , Gallstone and Gallbladder Polyp Patients.

TypeinterventionalSponsorChang Gung Memorial HospitalRan2015 to 2018Enrolled600ConditionsFluorenscent Image Guided Surgery, Indocyanide GreenArmsICG GB, ICG IV, LC conventional, LC conventional and IOC
NCT04908826 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Comparison of Administration of Indocyanine Green (ICG) for Image-Guided Laparoscopic Cholocystectomy- A Randomized, Controlled, Prospective Trial

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2022 to 2023Enrolled240ConditionsLaparoscopic, Cholecystectomy, Cholelithiasis, Bile DuctArmsIndocyanine Green (ICG) administration
NCT05072717 nawithdrawnnot on this mapstarted 2022, after this paper: background citation

Single-center Pilot Prospective Observational Study to Determine Feasibility of Assessing Meniscal Tissue Vascularity Using Dynamic Contrast-enhanced Fluorescence Arthroscopy

TypeinterventionalSponsorDartmouth-Hitchcock Medical CenterRan2022 to 2023Enrolled0ConditionsKnee InjuriesArmsPerfusion with Indocyanine green
NCT06198400 narecruitingnot on this mapstarted 2024, after this paper: background citation

Indocyanine Green Fluorescence in Evaluation of Post-resection Pancreatic Remnant Perfusion After Pancreaticoduodenectomy

TypeinterventionalSponsorCharles University, Czech RepublicRan2024 to 2027Enrolled60ConditionsPancreatic FistulaArmsPerioperative assessment of the perfusion of post-resection pancreatic remnant using indocyanine green-VerDye
3 · Its place in the literature

Who cites it

243 citing papers in PubMed, 8 syntheses or guidelines pooled it, 523 citations in OpenAlex.

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  19. Colour-Guided Surgery: A Conceptual Framework for Multimodal Intraoperative Visualisation-A Narrative Review.The international journal of medical robotics + computer assisted surgery : MRCAS · 2026
    Review
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183 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Luigi BoniMinimally Invasive Surgery Research Center, Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy, luigi.boni@uninsubria.it.
Giulia David
Alberto Mangano
Gianlorenzo Dionigi
Stefano Rausei
Sebastiano Spampatti
Elisa Cassinotti
Abe Fingerhut
University of Insubria · ITMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecently major developments in video imaging have been achieved: among these, the use of high definition and 3D imaging systems, and more recently indocyanine green (ICG) fluorescence imaging are emerging as major contributions to intraoperative decision making during surgical procedures. The aim of this study was to present our experience with different laparoscopic procedures using ICG fluorescence imaging. PATIENTS AND

methods108 ICG-enhanced fluorescence-guided laparoscopic procedures were performed: 52 laparoscopic cholecystectomies, 38 colorectal resections, 8 living-donor nephrectomies, 1 laparoscopic kidney autotransplantation, 3 inguino-iliac/obturator lymph node dissections for melanoma, and 6 miscellanea procedures. Visualization of structures was provided by a high definition stereoscopic camera connected to a 30° 10 mm scope equipped with a specific lens and light source emitting both visible and near infra-red (NIR) light (KARL STORZ GmbH & Co. KG, Tuttlingen, Germany). After injection of ICG, the system projected high-resolution NIR real-time images of blood flow in vessels and organs as well as highlighted biliary excretion .

resultsNo intraoperataive or injection-related adverse effects were reported, and the biliary/vascular anatomy was always clearly identified. The imaging system provided invaluable information to conduct a safe cholecystectomy and ensure adequate vascular supply for colectomy, nephrectomy, or find lymph nodes. There were no bile duct injuries or anastomotic leaks.

conclusionsIn our experience, the ICG fluorescence imaging system seems to be simple, safe, and useful. The technique may well become a standard in the near future in view of its different diagnostic and oncological capabilities. Larger studies and more specific evaluations are needed to confirm its role and to address its disadvantages.

Indexed as

Coloring AgentsIndocyanine GreenAgedBile DuctsCholecystectomy, LaparoscopicColectomyColonFemaleGermanyHumansKidneyLaparoscopyLiving DonorsLymph Node ExcisionLymph NodesMaleColoring AgentsIndocyanine Green

Identifiers

PMID25303914
PMCPMC4471386
OpenAlexW1998588165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.