Evidence map›Paper›PMID 25303795›Full record

ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)

Platelet-derived microparticles generated by neonatal extracorporeal membrane oxygenation systems.

Andrew D Meyer, Jonathan A L Gelfond, Andrew A Wiles, Robert J Freishtat, Khoydar Rais-Bahrami

Registry-linked trialOpen access · greenAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02940327 (A Feasibility Study to Consider the Relationship Between Markers of Red Cell Damage, Inflammation and the Recovery Process of Newborns Requiring Extracorporeal Membrane Oxygenation), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02940327 completednot on this map

A Feasibility Study to Consider the Relationship Between Markers of Red Cell Damage, Inflammation and the Recovery Process of Newborns Requiring Extracorporeal Membrane Oxygenation (ECMO) for Persistent Pulmonary Hypertension of the Newborn (PPHN): Mi-ECMO

TypeobservationalSponsorUniversity of LeicesterRan2016 to 2017Enrolled24ConditionsPersistent Pulmonary Hypertension of the Newborn
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Hemostasis in neonatal ECMO.Frontiers in pediatrics · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Platelet Transfusion Practice and Related Outcomes in Pediatric Extracorporeal Membrane Oxygenation.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Device-Induced Hemostatic Disorders in Mechanically Assisted Circulation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrew D MeyerFrom the *Division of Pediatric Critical Care, Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas; †Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, Texas; ‡Department of Integrative Systems Biology, Children's National Medical Center, Washington, District of Columbia; and §Division of Neonatology, Center for Hospital-based Subspecialties, Children National Medical Center, Washington, District of Columbia.
Jonathan A L Gelfond
Andrew A Wiles
Robert J Freishtat
Khoydar Rais-Bahrami
The University of Texas Health Science Center at San Antonio · USChildren's National · US

Funding

Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthKL2TR001118 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, DOUGHERTY, DONALD M · 2013 to 2017
$3.4M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthKL2TR000118 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A · 2012 to 2013
$757k
NCATS NIH HHS KL2 TR000118NCATS NIH HHS KL2 TR001118NCATS NIH HHS UL1 TR001120
6 · The paper itself

Abstract

Current anticoagulation strategies do not eliminate thromboembolic stroke or limb loss during neonatal extracorporeal membrane oxygenation (ECMO), a form of cardiopulmonary bypass (CPB). In adults, CPB surgery generates prothrombotic platelet-derived microparticles (PMPs), submicron membrane vesicles released from activated platelets. However, information on PMP generation in neonatal ECMO systems is lacking. The objective of this study was to compare PMP generation in five different neonatal ECMO systems, using a simulated circuit with swine blood at 300 ml/min for 4 hours. Systems were composed of both newer components (centrifugal pump and hollow-fiber oxygenator) and traditional components (roller-head pump and silicone membrane oxygenator). Free plasma hemoglobin levels were measured as an indicator of hemolysis and flow cytometry-measured PMP. Hemolysis generated in all ECMO systems was similar to that observed in noncirculated static blood (p = 0.48). There was no difference in net PMP levels between different oxygenators with a given pump. In contrast, net PMP generation in ECMO systems with a centrifugal pump was at least 2.5 times greater than in roller-head pump systems. This was significant when using either a hollow-fiber (p < 0.005) or a silicone membrane (p < 0.05) oxygenator. Future studies are needed to define the relationship between pump-generated PMP and thrombosis.

Indexed as

AnimalsBlood PlateletsCell-Derived MicroparticlesEquipment DesignExtracorporeal Membrane OxygenationHemolysisHumansInfant, NewbornIn Vitro TechniquesModels, AnimalModels, CardiovascularSwine

Identifiers

PMID25303795
PMCPMC4628788
OpenAlexW1972961824

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.