ReviewEnvironmental health perspectives2015
Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine.
Review in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A meta-analysis of the effects of community-based treatments for asthma in children.BMC pediatrics · 2025Pooled it
- Update of a systematic review on associations between environmental exposures and asthma control and exacerbations in young children.BMJ open · 2025Pooled it
- Childhood Physical Health and Attention Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Modifiable Factors.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- Association of indoor microbial aerosols with respiratory symptoms among under-five children: a systematic review and meta-analysis.Environmental health : a global access science source · 2021Pooled it
- Effectiveness of Interventions to Reduce Tobacco Smoke Pollution in Homes: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2015Pooled it
- Measured air quality impacts after teaching parents about cooking ventilation with a video: a pilot study.Journal of exposure science & environmental epidemiology · 2025Trial
- The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses.Nutrients · 2022Trial
- Treatment by biomarker-informed endotype vs guideline care in children with difficult-to-treat asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Trial
- Effect of vitamin D supplementation on total and allergen-specific IgE in children with asthma and low vitamin D levels.The Journal of allergy and clinical immunology · 2022Trial
- Trial
- Domestic fungal exposure and asthma morbidity in New York City children following Superstorm Sandy.Journal of exposure science & environmental epidemiology · 2026Article
- The effect of damp housing on psychological distress: does respiratory health matter?American journal of epidemiology · 2026Article
- Associations between reservoir bedroom dust allergen levels and sleep symptoms in school-age children.Sleep health · 2026Article
- Pollutant particle priming amplifies airway compartment specific neutrophil and macrophage inflammatory programs following house dust mite acute exposure.Frontiers in immunology · 2026Article
- Role of the protease-activated receptor 2 in multi-walled carbon nanotube-induced macrophage polarizationFrontiers in toxicology · 2026Article
- Exposure to Air Pollution and the Prevalence of Respiratory Symptoms in Northeast Ohio Farmworkers.Journal of immigrant and minority health · 2025Article
- Using mHealth to Predict Asthma Exacerbations in Children and Adolescents (Mobile Health for Kids With Asthma): Protocol for an Observational Study.JMIR research protocols · 2025Article
- Home exposure to moisture and mold is associated with poorer asthma control in children: CHAMPIASTHMA study.The journal of allergy and clinical immunology. Global · 2025Article
- Cockroach Microbiome Disrupts Indoor Environmental Microbial Ecology with Potential Public Health Implications.Environment & health (Washington, D.C.) · 2025Article
- Indoor bioaerosols and asthma: Overview, implications, and mitigation strategies.The Journal of allergy and clinical immunology · 2025Review
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundPrevious research has found relationships between specific indoor environmental exposures and exacerbation of asthma.
objectivesIn this review we provide an updated summary of knowledge from the scientific literature on indoor exposures and exacerbation of asthma.
methodsPeer-reviewed articles published from 2000 to 2013 on indoor exposures and exacerbation of asthma were identified through PubMed, from reference lists, and from authors' files. Articles that focused on modifiable indoor exposures in relation to frequency or severity of exacerbation of asthma were selected for review. Research findings were reviewed and summarized with consideration of the strength of the evidence.
resultsSixty-nine eligible articles were included. Major changed conclusions include a causal relationship with exacerbation for indoor dampness or dampness-related agents (in children); associations with exacerbation for dampness or dampness-related agents (in adults), endotoxin, and environmental tobacco smoke (in preschool children); and limited or suggestive evidence for association with exacerbation for indoor culturable Penicillium or total fungi, nitrogen dioxide, rodents (nonoccupational), feather/down pillows (protective relative to synthetic bedding), and (regardless of specific sensitization) dust mite, cockroach, dog, and dampness-related agents. DISCUSSION: This review, incorporating evidence reported since 2000, increases the strength of evidence linking many indoor factors to the exacerbation of asthma. Conclusions should be considered provisional until all available evidence is examined more thoroughly.
conclusionMultiple indoor exposures, especially dampness-related agents, merit increased attention to prevent exacerbation of asthma, possibly even in nonsensitized individuals. Additional research to establish causality and evaluate interventions is needed for these and other indoor exposures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.