ArticleBritish dental journal2014
Reduction in unstimulated salivary flow rate in burning mouth syndrome.
Article in British dental journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Evaluation of laser therapy and alpha-lipoic acid for the treatment of burning mouth syndrome: a randomized clinical trial.Lasers in medical science · 2018Trial
- Burning Mouth Syndrome, the Oral Microbiome, and Lactic Acid Bacteria: A Comprehensive Review of Clinical Features, Microbial Dysbiosis, and Probiotic Therapeutic Potential.Microorganisms · 2026Review
- Associations between traditional Chinese medicine syndrome types, emotion and immune function in patients with burning mouth syndrome.Odontology · 2026Article
- Cross-Cultural Differences and Clinical Presentations in Burning Mouth Syndrome: A Cross-Sectional Comparative Study of Italian and Romanian Outpatient Settings.Journal of clinical medicine · 2025Article
- Challenges of Diagnosis and Management of Burning Mouth Syndrome: A Literature Review.Current aging science · 2025Review
- Current developments and opportunities of pluripotent stem cells-based therapies for salivary gland hypofunction.Frontiers in cell and developmental biology · 2024Review
- Salivary Complaints in Burning Mouth Syndrome: A Cross Sectional Study on 500 Patients.Journal of clinical medicine · 2023Article
- Effects of self-perceived psychological stress on clinical symptoms, cortisol, and cortisol/ACTH ratio in patients with burning mouth syndrome.BMC oral health · 2023Article
- Xerogenic medications may contribute to decreased unstimulated salivary flow in patients with oral burning and/or gastro-esophageal reflux disease.Frontiers in dental medicine · 2023Article
- Smell and Taste Function and Their Disturbances in Sjögren's Syndrome.International journal of environmental research and public health · 2022Review
- Clinical Utility of Quantitative Parameters of Salivary Gland Scintigraphy for Diagnosing Burning Mouth Syndrome.Diagnostics (Basel, Switzerland) · 2022Article
- Candidiasis and Other Bacterial Infections among Patients Diagnosed with Burning Mouth Syndrome.Medicina (Kaunas, Lithuania) · 2022Article
- Salivary characteristics may be associated with burning mouth syndrome?Journal of clinical and experimental dentistry · 2021Article
- Chemosensory dysfunction, Oral disorders and Oral health-related quality of life in patients with primary Sjögren's syndrome: comparative cross-sectional study.BMC oral health · 2020Article
- Oral burning: local and systemic connection for a patient-centric approach.The EPMA journal · 2019Review
- Article
- Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors.International journal of medical sciences · 2018Review
- Is it Sjögren's syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms.Oral surgery, oral medicine, oral pathology and oral radiology · 2017Review
- Summary of: reduction in unstimulated salivary flow rate in burning mouth syndrome.British dental journal · 2014Article
- Evaluation and management of dry mouth and its complications in rheumatology practice.Expert review of clinical immunologyReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBurning mouth syndrome (BMS) is a chronic condition of burning of the tongue and oral mucosa. It is often accompanied with complaints of xerostomia, although it is unknown whether the dryness is a sensory change similar to the burning sensation or due to hyposalivation. To determine whether there is change in salivary flow rate, whole salivary flows were measured in BMS patients.
methodsA clinical ambispective study was conducted. Patients' clinical files were reviewed for stimulated and unstimulated whole salivary flow. Patients were divided into four groups based on diagnosis into Sjögren's syndrome (SS), BMS, BMS taking oral drying medications (BMS-med), and control (C). Whole stimulated (SF) and unstimulated flow (USF) measurements were collected and compared among groups. Data were analysed with ANOVA, Levene's test, Tukey's test and Games-Howell test.
resultsTwenty SS, 22 BMS, 24 BMS-med and 15 C were included in the study. SF was significantly lower in SS (0.59 ml ± 0.36) compared with BMS (1.56 ml ± 0.65, p <0.001), BMS-med (1.44 ml ± 0.64, p <0.001) and C (2.32 ml ± 1.06, p = 0.001). USF was significantly lower in SS (0.12 ml ± 0.10) compared with BMS (0.30 ml ± 0.18, p = 0.002), BMS-med (0.27 ml ± 0.21, p = 0.022) and C (0.52 ml ± 0.26, p <0.001). SF was not significantly different between BMS and C (p = 0.172) and BMS-med and C (p = 0.096). Both BMS and BMS-med had significantly lower USF compared with C (p = 0.040 and p = 0.018 respectively). SF in BMS was not significantly affected by number of oral drying medications (p = 0.254); however, USF was significantly lower with two or more oral drying medications (0.13 ml ± 0.07) compared with one oral drying medication (0.32 ml ± 0.22) (p = 0.034).
conclusionBMS patients have statistically significant decreased unstimulated salivary flow rate with non-statistically significant decreased stimulated flow rate. Salivary flow rates in BMS patients are decreased further by medication usage whose side effects include dry mouth. This suggests that hyposalivation may play a role in causing dry mouth in BMS, which may respond to treatment with a sialogogue.
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