Evidence map›Paper›PMID 25303523›Full record

ReviewCell2014

Cellular differences in protein synthesis regulate tissue homeostasis.

Michael Buszczak, Robert A J Signer, Sean J Morrison

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 229 citations in OpenAlex.

  1. Article
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  3. Review
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  19. Nuclear actin is a critical regulator ofbioRxiv : the preprint server for biology · 2024
    Article
  20. Article

72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Michael BuszczakDepartment of Molecular Biology, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Robert A J SignerHoward Hughes Medical Institute, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Sean J MorrisonHoward Hughes Medical Institute, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: sean.morrison@utsouthwestern.edu.
Southwestern Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

The Regulation of Stem Cell AgingR37AG024945 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI MORRISON, SEAN J · 2009 to 2018
$3.1M
Decoding Stem Cell Chromatin Using DrosophilaR01GM086647 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI BUSZCZAK, MICHAEL · 2009 to 2013
$1.5M
The Regulation of Stem Cell AgingR01AG024945 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORRISON, SEAN J · 2004 to 2008
$1.1M
CIHR MFE-106993Howard Hughes Medical InstituteNIA NIH HHS R01 AG024945NIA NIH HHS R37 AG024945NIGMS NIH HHS R01 GM086647
6 · The paper itself

Abstract

Although sometimes considered a "house-keeping" function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner. These differences are required to establish and maintain differences in cell identity, cell function, tissue homeostasis, and tumor suppression.

Indexed as

Protein BiosynthesisAnimalsCell ProliferationHomeostasisHumansMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesNeoplasmsOrgan SpecificityRibosomesStem CellsTOR Serine-Threonine KinasesMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesTOR Serine-Threonine Kinases

Identifiers

PMID25303523
PMCPMC4222182
OpenAlexW1982599843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.