ArticlePloS one2014
Apparent Diffusion Coefficient (ADC) value: a potential imaging biomarker that reflects the biological features of rectal cancer.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pretreatment Apparent Diffusion Coefficient Cannot Predict Histopathological Features and Response to Neoadjuvant Radiochemotherapy in Rectal Cancer: A Meta-Analysis.Digestive diseases (Basel, Switzerland) · 2022Pooled it
- Tumor apparent diffusion coefficient as a predictive marker for PD-1 inhibitor outcome in advanced cervical cancer: a retrospective study.Frontiers in oncology · 2026Article
- Low b-values in apparent diffusion coefficient calculations overestimate diffusion in rectal cancer.Acta oncologica (Stockholm, Sweden) · 2025Observational
- Early response prediction during radiotherapy in rectal cancer using sequential diffusion-weighted imaging at a magnetic resonance image-guided linear accelerator.Physics and imaging in radiation oncology · 2025Article
- A novel pN stage prediction model for resectable rectal adenocarcinoma based on preoperative MRI features and multiregional apparent diffusion coefficients.European radiology · 2025Article
- Breast Imaging: Correlation Between Axillary Lymph Nodes Apparent Diffusion Coefficient and Pathological Lymphovascular Invasion in Patients With Invasive Breast Cancer.European journal of breast health · 2025Article
- Assessment of prognostic indicators and KRAS mutations in rectal cancer using a fractional-order calculus MR diffusion model: whole tumor histogram analysis.Abdominal radiology (New York) · 2025Article
- Utilization of diffusion-weighted derived mathematical models to predict prognostic factors of resectable rectal cancer.Abdominal radiology (New York) · 2024Article
- Histogram analysis based on intravoxel incoherent motion diffusion-weighted imaging for determining the perineural invasion status of rectal cancer.Quantitative imaging in medicine and surgery · 2024Article
- Article
- Apparent diffusion coefficient values predict response to brachytherapy in bulky cervical cancer.Radiation oncology (London, England) · 2024Article
- Texture analysis of apparent diffusion coefficient maps: can it identify nonresponse to neoadjuvant chemotherapy for additional radiation therapy in rectal cancer patients?Gastroenterology report · 2024Article
- Significance of apparent diffusion coefficient in diagnosis of rectal carcinoma.Frontiers in oncology · 2024Article
- The Multipurpose Usage of Diffusion-Weighted MRI in Rectal Cancer.Medicina (Kaunas, Lithuania) · 2023Article
- Repeatability of quantitative individual lesion and total disease multiparametric whole-body MRI measurements in prostate cancer bone metastases.The British journal of radiology · 2023Article
- High-resolution integrated dynamic shimming diffusion-weighted imaging (DWI) in the assessment of rectal cancer.European radiology · 2023Article
- Correlation between ADC, ADC ratio, and Gleason Grade group in prostate cancer patients undergoing radical prostatectomy: Retrospective multicenter study with different MRI scanners.Frontiers in oncology · 2023Article
- Article
- Diffusion-Weighted MRI as Non-Invasive Diagnostic Tool for Rectal Cancer Aggressiveness and Correlation with KI-67 Expression in Tumor Tissue.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Revisitation of imaging features of skull base chondrosarcoma in comparison to chordoma.Journal of neuro-oncology · 2022Article
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6 authors.
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Abstract
objectiveWe elected to analyze the correlation between the pre-treatment apparent diffusion coefficient (ADC) and the clinical, histological, and immunohistochemical status of rectal cancers. MATERIALS AND
methodsForty-nine rectal cancer patients who received surgical resection without neoadjuvant therapy were selected that underwent primary MRI and diffusion-weighted imaging (DWI). Tumor ADC values were determined and analyzed to identify any correlations between these values and pre-treatment CEA or CA19-9 levels, and/or the histological and immunohistochemical properties of the tumor.
resultsInter-observer agreement of confidence levels from two separate observers was suitable for ADC measurement (k = 0.775). The pre-treatment ADC values of different T stage tumors were not equal (p = 0.003). The overall trend was that higher T stage values correlated with lower ADC values. ADC values were also significantly lower for the following conditions: tumors with the presence of extranodal tumor deposits (p = 0.006) and tumors with CA19-9 levels ≥ 35 g/ml (p = 0.006). There was a negative correlation between Ki-67 LI and the ADC value (r = -0.318, p = 0.026) and between the AgNOR count and the ADC value (r = -0.310, p = 0.030).
conclusionSignificant correlations were found between the pre-treatment ADC values and T stage, extranodal tumor deposits, CA19-9 levels, Ki-67 LI, and AgNOR counts in our study. Lower ADC values were associated with more aggressive tumor behavior. Therefore, the ADC value may represent a useful biomarker for assessing the biological features and possible relationship to the status of identified rectal cancers.
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