ArticleMacromolecular rapid communications2014
The design of dextran-based hypoxia-inducible hydrogels via in situ oxygen-consuming reaction.
Article in Macromolecular rapid communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Manipulation of Oxygen Tension in Damaged Regions via Hypoxia-Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- HIF-stabilizing biomaterials: from hypoxia-mimicking to hypoxia-inducing.Materials advances · 2023Review
- Gas-modulating microcapsules for spatiotemporal control of hypoxia.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Polymeric biomaterials for wound healing.Frontiers in bioengineering and biotechnology · 2023Review
- Engineering Tools for Regulating Hypoxia in Tumour Models.Journal of cellular and molecular medicine · 2021Review
- Enzyme functionalized microgels enable precise regulation of dissolved oxygen and anaerobe culture.Materials today. Bio · 2021Article
- Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs.Advanced biosystems · 2019Article
- Stabilization of enzyme-immobilized hydrogels for extended hypoxic cell culture.Emergent materials · 2019Article
- Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis.Science advances · 2019Article
- A self-healing hydrogel as an injectable instructive carrier for cellular morphogenesis.Biomaterials · 2018Article
- Review
- In Situ Cross-Linkable Hydrogels as a Dynamic Matrix for Tissue Regenerative Medicine.Tissue engineering and regenerative medicine · 2018Review
- Biomimetic brain tumor niche regulates glioblastoma cells towards a cancer stem cell phenotype.Journal of neuro-oncology · 2018Article
- Bioinspired Hydrogels to Engineer Cancer Microenvironments.Annual review of biomedical engineering · 2017Review
- Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering.Biochemical and biophysical research communications · 2016Review
- Designer Hydrogels for Precision Control of Oxygen Tension and Mechanical Properties.Journal of materials chemistry. B · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Hypoxia plays a critical role in the development and wound healing process, as well as a number of pathological conditions. Here, dextran-based hypoxia-inducible (Dex-HI) hydrogels formed with in situ oxygen consumption via a laccase-medicated reaction are reported. Oxygen levels and gradients were accurately predicted by mathematical simulation. It is demonstrated that Dex-HI hydrogels provide prolonged hypoxic conditions up to 12 h. The Dex-HI hydrogel offers an innovative approach to delineate not only the mechanism by which hypoxia regulates cellular responses, but may facilitate the discovery of new pathways involved in the generation of hypoxic and oxygen gradient environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.