ReviewBiochemistry2015
Circadian genomics reveal a role for post-transcriptional regulation in mammals.
Review in Biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Phosphorylation and Circadian Molecular Timing.Frontiers in physiology · 2020Pooled it
- Advances in monitoring mammalian circadian components and their rhythms using reporter systems.RSC chemical biology · 2026Review
- Circadian clock and cancer.Military Medical Research · 2026Review
- EIDD-1931 Treatment Tweaks CYP3A4 and CYP2C8 in Arthritic Rats to Expedite Drug Interaction: Implication in Oral Therapy of Molnupiravir.ACS omega · 2024Article
- Coordination of rhythmic RNA synthesis and degradation orchestrates 24- and 12-h RNA expression patterns in mouse fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Circadian Pattern of Ion Channel Gene Expression in Failing Human Hearts.Circulation. Arrhythmia and electrophysiology · 2021Article
- The Making and Breaking of RNAs: Dynamics of Rhythmic RNA Expression in Mammals.Journal of biological rhythms · 2020Review
- Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression.PLoS computational biology · 2020Article
- Periodic Parasites and Daily Host Rhythms.Cell host & microbe · 2020Review
- Circadian clock genes and the transcriptional architecture of the clock mechanism.Journal of molecular endocrinology · 2019Review
- Chronobiology of limbic seizures: Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy.Neuroscience and biobehavioral reviews · 2019Review
- A period without PER: understanding 24-hour rhythms without classic transcription and translation feedback loops.F1000Research · 2019Review
- Identification and Characterization of Transcripts Regulated by Circadian Alternative Polyadenylation in Mouse Liver.G3 (Bethesda, Md.) · 2018Article
- A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer.EBioMedicine · 2018Article
- A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa.PLoS genetics · 2018Article
- Circadian Posttranscriptional Regulatory Mechanisms in Mammals.Cold Spring Harbor perspectives in biology · 2018Review
- Cardinal Epigenetic Role of non-coding Regulatory RNAs in Circadian Rhythm.Molecular neurobiology · 2018Review
- Emerging roles for microRNA in the regulation of Drosophila circadian clock.BMC neuroscience · 2018Review
- Extracellular Vesicles: Potential Participants in Circadian Rhythm Synchronization.International journal of biological sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To maintain daily cycles, the circadian clock must tightly regulate the rhythms of thousands of mRNAs and proteins with the correct period, phase, and amplitude to ultimately drive the wide range of rhythmic biological processes. Recent genomic approaches have revolutionized our view of circadian gene expression and highlighted the importance of post-transcriptional regulation in driving mRNA rhythmicity. Even after transcripts are made from DNA, subsequent processing and regulatory steps determine when, where, and how much protein will be generated. These post-transcriptional regulatory mechanisms can add flexibility to overall gene expression and alter protein levels rapidly without requiring transcript synthesis and are therefore beneficial for cells; however, the extent to which circadian post-transcriptional mechanisms contribute to rhythmic profiles throughout the genome and the mechanisms involved have not been fully elucidated. In this review, we will summarize how circadian genomics have revealed new insights into rhythmic post-transcriptional regulation in mammals and discuss potential implications of such regulation in controlling many circadian-driven physiologies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.