ArticlePloS one2014
A new ochratoxin A biodegradation strategy using Cupriavidus basilensis Őr16 strain.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Sex-Specific Renal Proteomic Responses to Mycotoxins and Their Mitigation by Bioactive Food Ingredients.Molecular nutrition & food research · 2026Article
- Molecular insights into ochratoxin A biodegradation.Biologia futura · 2025Review
- Biocontrol Agents and Natural Feed Supplements as a Safe and Cost-Effective Way for Preventing Health Ailments Provoked by Mycotoxins.Foods (Basel, Switzerland) · 2025Review
- Efficient degradation of neomycin byFrontiers in microbiology · 2025Article
- Negative Effects of Occurrence of Mycotoxins in Animal Feed and Biological Methods of Their Detoxification: A Review.Molecules (Basel, Switzerland) · 2024Review
- Comprehensive Insights into Ochratoxin A: Occurrence, Analysis, and Control Strategies.Foods (Basel, Switzerland) · 2024Review
- Natural feed additives and bioactive supplements versus chemical additives as a safe and practical approach to combat foodborne mycotoxicoses.Frontiers in nutrition · 2024Review
- Degradation of ochratoxins A and B by lipases: A kinetic study unraveled by molecular modeling.Heliyon · 2023Article
- New perspectives in application of kidney biomarkers in mycotoxin induced nephrotoxicity, with a particular focus on domestic pigs.Frontiers in microbiology · 2023Review
- Article
- Evaluation of the Safety and Ochratoxin A Degradation Capacity ofInternational journal of molecular sciences · 2022Article
- Bio-control on the contamination of Ochratoxin A in food: Current research and future prospects.Current research in food science · 2022Review
- Review
- Article
- Article
- Mycotoxin Biodegradation Ability of the Cupriavidus Genus.Current microbiology · 2020Article
- Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action.Molecules (Basel, Switzerland) · 2019Review
- Advances in Biodetoxification of Ochratoxin A-A Review of the Past Five Decades.Frontiers in microbiology · 2018Review
- Article
- Biodegradation of Mycotoxins: Tales from Known and Unexplored Worlds.Frontiers in microbiology · 2016Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ochratoxin-A (OTA) is a mycotoxin with possibly carcinogenic and nephrotoxic effects in humans and animals. OTA is often found as a contaminant in agricultural commodities. The aim of the present work was to evaluate OTA-degrading and detoxifying potential of Cupriavidus basilensis ŐR16 strain. In vivo administration of OTA in CD1 male mice (1 or 10 mg/kg body weight for 72 hours or 0.5 mg/kg body weight for 21 days) resulted in significant elevation of OTA levels in the blood, histopathological alterations- and transcriptional changes in OTA-dependent genes (annexinA2, clusterin, sulphotransferase and gadd45 and gadd153) in the renal cortex. These OTA-induced changes were not seen in animals that have been treated with culture supernatants in which OTA was incubated with Cupriavidus basilensis ŐR16 strain for 5 days. HPLC and ELISA methods identified ochratoxin α as the major metabolite of OTA in Cupriavidus basilensis ŐR16 cultures, which is not toxic in vivo. This study has demonstrated that Cupriavidus basilensis ŐR16 efficiently degrade OTA without producing toxic adventitious metabolites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.