ArticlePhysical review letters2014
Optimal point spread function design for 3D imaging.
Article in Physical review letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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Who cites it
132 citing papers in PubMed.
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- Optimal excitation polarization schemes to boost the precision of single-molecule orientation imaging.Biomedical optics express · 2026Article
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- Bypassing the imaging thickness limit with a translationally-invariant nonlocal thin film.Nature communications · 2026Article
- Deep Learning for Localization Microscopy in 2D and 3D.Accounts of chemical research · 2026Article
- CRISPR-Cas-based live cell imaging of genome dynamics.Nature reviews. Genetics · 2026Review
- Symmetric cancer spheroid-fibroblast organization revealed in 3D by high-throughput microscopy.Communications biology · 2026Article
- Chromatix: a differentiable, GPU-accelerated wave-optics library.Nature methods · 2026Article
- High-speed volumetric single-molecule imaging using dual-wavelength light sheets and PSF-engineered enhanced biplane detection.bioRxiv : the preprint server for biology · 2026Article
- Digital-micromirror-device-based illumination strategies for background suppression in single-molecule localization microscopy.Biomedical optics express · 2026Article
- 3D Single-Virus Tracking: Advances in Methodology and Labeling Strategies Towards Probing the Virus-Epithelium Interaction.Viruses · 2026Review
- Chromatix: a differentiable, GPU-accelerated wave-optics library.bioRxiv : the preprint server for biology · 2026Article
- Compact Spectral Encoding Microscopy by Terrace Grating Optics.ACS photonics · 2026Article
- Revisiting PSF models: Unifying framework and high-performance implementation.Journal of microscopy · 2026Article
- Separation estimation of two freely rotating dipole emitters near the quantum limit.Physical review. A · 2026Article
- Fabrication of Customized Diffractive Optics in under 10 Minutes via Single-Shot Grayscale Projection on a Consumer-Grade DLP System.ACS photonics · 2026Article
- Volumetric Single-Molecule Tracking Inside Subcellular Structures.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Information advantage in sensing revealed by Fano-resonant Fourier scatterometry.Nature communications · 2025Article
- One-click reconstruction in single-molecule localization microscopy via experimental parameter-aware deep learning.Npj imaging · 2025Article
72 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
To extract from an image of a single nanoscale object maximum physical information about its position, we propose and demonstrate a framework for pupil-plane modulation for 3D imaging applications requiring precise localization, including single-particle tracking and superresolution microscopy. The method is based on maximizing the information content of the system, by formulating and solving the appropriate optimization problem--finding the pupil-plane phase pattern that would yield a point spread function (PSF) with optimal Fisher information properties. We use our method to generate and experimentally demonstrate two example PSFs: one optimized for 3D localization precision over a 3 μm depth of field, and another with an unprecedented 5 μm depth of field, both designed to perform under physically common conditions of high background signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.