ArticlePloS one2014
Determinants of fatigue after first-ever ischemic stroke during acute phase.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Neuroimaging correlates of post-stroke fatigue: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Association of post-stroke fatigue with physical activity and physical fitness: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Analysis of factors influencing poor neurological outcomes in patients with acute ischemic stroke.Annals of medicine · 2025Article
- Post-stroke fatigue: a review of development, prevalence, predisposing factors, measurements, and treatments.Frontiers in neurology · 2023Review
- Pre-stroke physical activity in relation to post-stroke outcomes - linked to the International Classification of Functioning, Disability and Health (ICF): A scoping review.Journal of rehabilitation medicine · 2022Article
- Prevalence of fatigue after stroke: A systematic review and meta-analysis.European stroke journal · 2021Review
- Analysis of Factors Affecting Post-Stroke Fatigue: An Observational, Cross-Sectional, Retrospective Chart Review Study.Healthcare (Basel, Switzerland) · 2021Article
- Contribution of sleep quality to fatigue following a stroke: a cross-sectional study.BMC neurology · 2021Article
- Risk Factors and Imaging Mechanisms of Fatigue After Mild Ischemic Stroke: An Exploratory Study From a Single Chinese Center.Frontiers in neurology · 2021Article
- Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study.Frontiers in neurology · 2021Article
- Very Early Cognitive Screening and Self-Reported Feeling of Fatigue Three Months After Stroke.Frontiers in human neuroscience · 2021Article
- Prevalence, Trajectory, and Predictors of Poststroke Fatigue among Ghanaians.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Article
- The Association of Autonomic Nervous System Function With Ischemic Stroke, and Treatment Strategies.Frontiers in neurology · 2019Review
- Pituitary dysfunction and association with fatigue in stroke and other acute brain injury.Endocrine connections · 2018Review
- Post-stroke Mood and Emotional Disturbances: Pharmacological Therapy Based on Mechanisms.Journal of stroke · 2016Review
- Neuroprotective mechanism of HIF-1α overexpression in the early stage of acute cerebral infarction in rats.Experimental and therapeutic medicine · 2016Article
- Clinical Utility of Mindfulness Training in the Treatment of Fatigue After Stroke, Traumatic Brain Injury and Multiple Sclerosis: A Systematic Literature Review and Meta-analysis.Frontiers in psychology · 2016Review
- Influence of Medication on Fatigue Six Months after Stroke.Stroke research and treatment · 2016Article
- Observational
- Factors Associated with Poststroke Fatigue: A Systematic Review.Stroke research and treatment · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeFatigue after stroke is common and has a negative impact on rehabilitation and survival. However, its pathogenesis and contributing factors remain unclear. The purpose of this study was to identify factors influencing the occurrence of fatigue after first-ever ischemic stroke in acute phase.
methodsWe examined 265 consecutive patients with first-ever ischemic stroke during acute phase (within 2 weeks) in two tertiary stroke care hospitals in Henan, China. We documented patients' demographic and clinical characteristics through face-to-face interviews using structured questionnaires and reviews of medical records. Post-stroke fatigue was defined as a score of ≥4 using the Fatigue Severity Scale. Multivariate logistic regression was used to examine post-stroke fatigue in relation to socio-demographic, lifestyle, clinical characteristics and family function.
resultsAbout 40% first-ever ischemic stroke patients experienced post-stroke fatigue in acute phase. Post-stroke fatigue was associated with lack of exercise before stroke (adjusted odds ratio 4.01, 95% CI 1.95-8.24), family dysfunction (2.63, 1.20-5.80), depression (2.39, 1.02-5.58), the presence of pre-stroke fatigue (4.89, 2.13-11.21), use of sedative medications (4.14, 1.58-10.88), coronary heart disease (3.38, 1.46-7.79) and more severe Modified Rankin Scale (2.55, 1.65-3.95).
conclusionsThe causes of post-stroke fatigue are multifaceted. More physical exercise, improving family function, reducing depression and appropriate use of sedative medications may be helpful in preventing post-stroke fatigue.
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Registered trials
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