ArticlePloS one2014
Calcifications of the thoracic aorta on extended non-contrast-enhanced cardiac CT.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies.Arteriosclerosis, thrombosis, and vascular biology · 2024Pooled it
- Can an Unenhanced Reduced-Dose ECG-Gated CT of the Aorta Replace an ECG-Gated CT-Angiography for Diameter Follow-Up of the Ascending Aorta?Journal of cardiovascular development and disease · 2026Article
- Determinants of thoracic aortic calcification and its effects on thoracic aortic size.The international journal of cardiovascular imaging · 2025Article
- Calcification of the Thoracic Aorta and Its Segments and Chronic Kidney Disease in Participants of the ELSA-Brasil Cohort.International journal of nephrology · 2025Article
- Thoracic versus coronary calcification for atherosclerotic cardiovascular disease events prediction.Heart (British Cardiac Society) · 2024Article
- Aortic Arch Calcification in Predicting Unfavorable Angiographic Outcomes for Patients with ST-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Article
- Magnetic Resonance Imaging and Computed Tomography for the Noninvasive Assessment of Arterial Aging: A Review by the VascAgeNet COST Action.Journal of the American Heart Association · 2023Review
- Acute Ischemic Stroke and Transient Ischemic Attack in ST-Segment Elevation Myocardial Infarction Patients Who Underwent Primary Percutaneous Coronary Intervention.Journal of clinical medicine · 2023Article
- Relationship between ectopic calcifications and bone fragility depicted on computed tomography scan in 70 patients with systemic sclerosis.Journal of scleroderma and related disorders · 2022Article
- Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study.The Lancet regional health. Western Pacific · 2022Article
- Aortic arch calcification: A simple but powerful marker of subclinical cardiovascular disease.The Lancet regional health. Western Pacific · 2022Article
- Aortic arch calcification with pericardial fat mass detected on a single chest X-ray image is closely associated with the predictive variables of future cardiovascular disease.Heart and vessels · 2022Article
- The Relationship Between Aortic Arch Calcification and Recurrent Stroke in Patients With Embolic Stroke of Undetermined Source-A Case-Control Study.Frontiers in neurology · 2022Article
- Thoracic Aorta Calcium Detection and Quantification Using Convolutional Neural Networks in a Large Cohort of Intermediate-Risk Patients.Tomography (Ann Arbor, Mich.) · 2021Article
- Cardiovascular magnetic resonance for the detection of descending thoracic aorta calcification in patients with end-stage renal disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Article
- Dexamethasone is Associated With a Lower Risk of the Progression of Thoracic Aortic Calcification in Breast Cancer Survivors.Frontiers in pharmacology · 2021Article
- Association of calcium density in the thoracic aorta with risk factors and clinical events.European radiology · 2020Article
- Anatomical References to Evaluate Thoracic Aorta Calcium by Computed Tomography.Current atherosclerosis reports · 2019Review
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe presence of calcified atherosclerosis in different vascular beds has been associated with a higher risk of mortality. Thoracic aorta calcium (TAC) can be assessed from computed tomography (CT) scans, originally aimed at coronary artery calcium (CAC) assessment. CAC screening improves cardiovascular risk prediction, beyond standard risk assessment, whereas TAC performance remains controversial. However, the curvilinear portion of the thoracic aorta (TA), that includes the aortic arch, is systematically excluded from TAC analysis. We investigated the prevalence and spatial distribution of TAC all along the TA, to see how those segments that remain invisible in standard TA evaluation were affected. METHODS AND
resultsA total of 970 patients (77% men) underwent extended non-contrast cardiac CT scans including the aortic arch. An automated algorithm was designed to extract the vessel centerline and to estimate the vessel diameter in perpendicular planes. Then, calcifications were quantified using the Agatston score and associated with the corresponding thoracic aorta segment. The aortic arch and the proximal descending aorta, "invisible" in routine CAC screening, appeared as two vulnerable sites concentrating 60% of almost 11000 calcifications. The aortic arch was the most affected segment per cm length. Using the extended measurement method, TAC prevalence doubled from 31% to 64%, meaning that 52% of patients would escape detection with a standard scan. In a stratified analysis for CAC and/or TAC assessment, 111 subjects (46% women) were exclusively identified with the enlarged scan.
conclusionsCalcium screening in the TA revealed that the aortic arch and the proximal descending aorta, hidden in standard TA evaluations, concentrated most of the calcifications. Middle-aged women were more prone to have calcifications in those hidden portions and became candidates for reclassification.
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Registered trials
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