SynthesisJournal of thrombosis and haemostasis : JTH2014
Thrombosis: a major contributor to the global disease burden.
Synthesis in Journal of thrombosis and haemostasis : JTH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 212 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exclusion of Venous Thrombo-Embolism With a New Clinical Decision Support With Fresh Plasma, on Any Patient With VTE Suspicion
Adherence to International Guidelines Directed Risk Stratification and Management of Acute Pulmonary Embolism, an Egyptian Experience
A Multi-center Cohort Study for Conventional Ultrasound Image Set Collection to Create a Training Data Set for Research Purposes (Image Processing and Analysis, AI Model Training).
Who cites it
212 citing papers in PubMed, 11 syntheses or guidelines pooled it, 474 citations in OpenAlex.
- Therapeutic Enoxaparin Dosing in Obesity.The Annals of pharmacotherapy · 2025Pooled it
- Statins for the primary prevention of venous thromboembolism.The Cochrane database of systematic reviews · 2024Pooled it
- Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis.Health technology assessment (Winchester, England) · 2024Pooled it
- Artificial intelligence in the prediction of venous thromboembolism: A systematic review and pooled analysis.European journal of haematology · 2023Pooled it
- Rivaroxaban Pharmacokinetics in Obese Subjects: A Systematic Review.Clinical pharmacokinetics · 2022Pooled it
- Thromboembolic events in left ventricular non-compaction: comparison between children and adults - a systematic review and meta-analysis.Open heart · 2022Pooled it
- Risk assessment models for venous thromboembolism in hospitalised adult patients: a systematic review.BMJ open · 2021Pooled it
- Global epidemiology of venous thromboembolism in people with active tuberculosis: a systematic review and meta-analysis.Journal of thrombosis and thrombolysis · 2021Pooled it
- Pharmacological thromboprophylaxis to prevent venous thromboembolism in patients with temporary lower limb immobilization after injury: systematic review and network meta-analysis.Journal of thrombosis and haemostasis : JTH · 2020Pooled it
- Individual risk factors predictive of venous thromboembolism in patients with temporary lower limb immobilization due to injury: a systematic review.Journal of thrombosis and haemostasis : JTH · 2019Pooled it
- Efficacy and safety of low-molecular-weight heparin after knee arthroscopy: A meta-analysis.PloS one · 2018Pooled it
- A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin, a novel recombinant anticoagulant protein, in healthy subjects.Pharmacology research & perspectives · 2021Trial
- Rosuvastatin use reduces thrombin generation potential in patients with venous thromboembolism: a randomized controlled trial.Journal of thrombosis and haemostasis : JTH · 2019Trial
- Engineering neurovascular thrombosis: Light-based bioprinting for patient-specific modeling and women's cerebrovascular health.Science advances · 2026Review
- Modification and validation of the Padua prediction score for assessing the risk of venous thromboembolism in medical inpatients: a case-control study.Clinics (Sao Paulo, Brazil) · 2026Article
- Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis.Cell research · 2026Article
- In-hospital DVT detection, thromboprophylaxis practice, and guideline adherence in patients with traumatic fractures: a single-center retrospective study.Research and practice in thrombosis and haemostasis · 2026Article
- Neutrophil-to-lymphocyte ratio is associated with 30-day mortality in acute pulmonary embolism across European Society of Cardiology risk categories.Research and practice in thrombosis and haemostasis · 2026Article
- National trends in venous thromboembolism incidence in Ireland (2015-2022): a retrospective analysis.Research and practice in thrombosis and haemostasis · 2026Observational
- Plasma Metabolomics of Thrombectomy-Treated Patients Highlights Metabolic Pathways Underlying Disease and Recovery.CNS neuroscience & therapeutics · 2026Article
152 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 10 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thrombosis is a common pathology underlying ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2010 documented that ischemic heart disease and stroke collectively caused one in four deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability. We performed a systematic review of the literature on the global disease burden caused by VTE in low-income, middle-income and high-income countries. Studies from western Europe, North America, Australia and southern Latin America (Argentina) yielded consistent results, with annual incidence rates ranging from 0.75 to 2.69 per 1000 individuals in the population. The incidence increased to between 2 and 7 per 1000 among those aged ≥ 70 years. Although the incidence is lower in individuals of Chinese and Korean ethnicity, their disease burden is not low, because of population aging. VTE associated with hospitalization was the leading cause of disability-adjusted life-years (DALYs) lost in low-income and middle-income countries, and the second most common cause in high-income countries, being responsible for more DALYs lost than nosocomial pneumonia, catheter-related bloodstream infections, and adverse drug events. VTE causes a major burden of disease across low-income, middle-income and high-income countries. More detailed data on the global burden of VTE should be obtained to inform policy and resource allocation in health systems, and to evaluate whether improved utilization of preventive measures will reduce the burden.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.