ArticleNature communications2014
Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.
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Who cites it
145 citing papers in PubMed.
- Spatial constraints determine the spread of plasmid-encoded antibiotic resistance between bacterial colonies.mSystems · 2026Article
- Resistance potentiators: Evolutionary catalysts of antibiotic resistance.PLoS biology · 2026Article
- Modelling the role of the microbiome in antimicrobial resistance across scales.Nature microbiology · 2026Review
- Do plasmid-dependent phages enable the survival of costly plasmids?bioRxiv : the preprint server for biology · 2026Article
- Heterogeneous multicopy of blaNature communications · 2026Article
- Article
- Klebsiella ARO112 promotes microbiota recovery, pathobiont clearance and prevents inflammation in IBD mice.Nature communications · 2025Article
- Plasmid-Mediated Spread of Antibiotic Resistance by Arsenic and Microplastics During Vermicomposting.Antibiotics (Basel, Switzerland) · 2025Article
- Flavomycin inhibits plasmid-mediated conjugative transfer of antibiotic resistance genes by disrupting energy metabolism and pilus assembly.Zoological research · 2025Article
- Dynamical memory underlies prolonged plasmid persistence after transient antibiotic treatment.bioRxiv : the preprint server for biology · 2025Article
- Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance.npj antimicrobials and resistance · 2025Review
- Abundance measurements reveal the balance between lysis and lysogeny in the human gut microbiome.Current biology : CB · 2025Article
- Evolution of a Plasmid Regulatory Circuit Ameliorates Plasmid Fitness Cost.Molecular biology and evolution · 2025Article
- Fitness and adaptive evolution of a Rhodococcus sp. harboring dioxin-catabolic plasmids.World journal of microbiology & biotechnology · 2025Article
- Chromosomal capture of beneficial genes drives plasmids toward ecological redundancy.The ISME journal · 2025Article
- Protozoa-enhanced conjugation frequency alters the dissemination of soil antibiotic resistance.The ISME journal · 2025Article
- Article
- The evolutionary landscape of prokaryotic chromosome/plasmid balance.Communications biology · 2024Article
- Hijackers, hitchhikers, or co-drivers? The mysteries of mobilizable genetic elements.PLoS biology · 2024Article
- Compensatory evolution of chromosomes and plasmids counteracts the plasmid fitness cost.Ecology and evolution · 2024Article
85 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Plasmids are important drivers of bacterial evolution, but it is challenging to understand how plasmids persist over the long term because plasmid carriage is costly. Classical models predict that horizontal transfer is necessary for plasmid persistence, but recent work shows that almost half of plasmids are non-transmissible. Here we use a combination of mathematical modelling and experimental evolution to investigate how a costly, non-transmissible plasmid, pNUK73, can be maintained in populations of Pseudomonas aeruginosa. Compensatory adaptation increases plasmid stability by eliminating the cost of plasmid carriage. However, positive selection for plasmid-encoded antibiotic resistance is required to maintain the plasmid by offsetting reductions in plasmid frequency due to segregational loss. Crucially, we show that compensatory adaptation and positive selection reinforce each other's effects. Our study provides a new understanding of how plasmids persist in bacterial populations, and it helps to explain why resistance can be maintained after antibiotic use is stopped.
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