ArticleEnvironmental health perspectives2015
Air pollution and percent emphysema identified by computed tomography in the Multi-Ethnic study of Atherosclerosis.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Structural and social determinants of health: The multi-ethnic study of atherosclerosis.PloS one · 2024Article
- Ambient fine particulate matter and allergic symptoms in the middle-aged and elderly population: results from the PIFCOPD study.Respiratory research · 2023Article
- Higher alveolar deposition of particulate matter in emphysematous lobes of COPD.ERJ open research · 2021Article
- Article
- Association Between Air Pollution and Lung Lobar Emphysema in COPD.Frontiers in medicine · 2021Article
- Long-term exposure to PMRespiratory research · 2020Article
- Short term association between air pollution (PMScientific reports · 2020Article
- The effects of fine and coarse particulate matter on lung function among the elderly.Scientific reports · 2019Observational
- Exposure to Atmospheric Ultrafine Particles Induces Severe Lung Inflammatory Response and Tissue Remodeling in Mice.International journal of environmental research and public health · 2019Article
- Exposure assessment of particulate matter and blood chromium levels in people living near a cement plant.Environmental geochemistry and health · 2018Article
- Exposure to Traffic Emissions and Fine Particulate Matter and Computed Tomography Measures of the Lung and Airways.Epidemiology (Cambridge, Mass.) · 2018Article
- Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air-lung study.The European respiratory journal · 2017Observational
- Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study.BMJ open respiratory research · 2017Article
- Advances in Understanding Air Pollution and CVD.Global heart · 2016Review
- Particulate Matter Exposure and Cardiopulmonary Differences in the Multi-Ethnic Study of Atherosclerosis.Environmental health perspectives · 2016Article
- Emphysema prevalence related air pollution caused by a cement plant.Annals of occupational and environmental medicine · 2016Article
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundAir pollution is linked to low lung function and to respiratory events, yet little is known of associations with lung structure.
objectivesWe examined associations of particulate matter (PM2.5, PM10) and nitrogen oxides (NOx) with percent emphysema-like lung on computed tomography (CT).
methodsThe Multi-Ethnic Study of Atherosclerosis (MESA) recruited participants (45-84 years of age) in six U.S. states. Percent emphysema was defined as lung regions < -910 Hounsfield Units on cardiac CT scans acquired following a highly standardized protocol. Spirometry was also conducted on a subset. Individual-level 1- and 20-year average air pollution exposures were estimated using spatiotemporal models that included cohort-specific measurements. Multivariable regression was conducted to adjust for traditional risk factors and study location.
resultsAmong 6,515 participants, we found evidence of an association between percent emphysema and long-term pollution concentrations in an analysis leveraging between-city exposure contrasts. Higher concentrations of PM2.5 (5 μg/m3) and NOx (25 ppb) over the previous year were associated with 0.6 (95% CI: 0.1, 1.2%) and 0.5 (95% CI: 0.1, 0.9%) higher average percent emphysema, respectively. However, after adjustment for study site the associations were -0.6% (95% CI: -1.5, 0.3%) for PM2.5 and -0.5% (95% CI: -1.1, 0.02%) for NOx. Lower lung function measures (FEV1 and FVC) were associated with higher PM2.5 and NOx levels in 3,791 participants before and after adjustment for study site, though most associations were not statistically significant.
conclusionsAssociations between ambient air pollution and percentage of emphysema-like lung were inconclusive in this cross-sectional study, thus longitudinal analyses may better clarify these associations with percent emphysema.
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