ArticleBioMed research international2014
Cigarette smoke-exposed Candida albicans increased chitin production and modulated human fibroblast cell responses.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
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- In Vitro Exposure to Vaped Tetrahydrocannabinol IncreasesMicroorganisms · 2025Article
- New Curcumin Analogue (PAC) InhibitsAntibiotics (Basel, Switzerland) · 2025Article
- The Effect of a Secondary Stressor on the Morphology and Membrane Structure of an Already Challenged Maternal and Foetal Red Blood Cell Population.International journal of molecular sciences · 2025Article
- Mechanistic insight into the anti-alternaria activity of bimetallic zinc oxide and silver/zinc oxide nanoparticles.Heliyon · 2024Article
- Appraisal and characterization of candida load isolated from the oral cavity of smokers.Saudi journal of biological sciences · 2023Article
- Unexpected Candidal Hyphae in Oral Mucosa Lesions-A Clinico-Pathological Study.Antibiotics (Basel, Switzerland) · 2022Article
- Whole Salivary Cotinine Levels and Interleukin 1-β Levels among Young Adults Involuntarily Exposed to Vapor from Electronic Nicotine Delivery Systems.Oral health & preventive dentistry · 2022Article
- Oral health status among transgender young adults: a cross-sectional study.BMC oral health · 2021Article
- Smoking-aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome.Journal of cellular and molecular medicine · 2021Article
- The Discrepancy between Clove and Non-Clove Cigarette Smoke-PromotedF1000Research · 2021Article
- Looking beyond the smokescreen: can the oral microbiome be a tool or target in the management of tobacco-associated oral cancer?Ecancermedicalscience · 2021Review
- Clinical Characteristics and Manifestations of Fungal Esophagitis: A Single-Center Experience in South China.Gastroenterology research and practice · 2021Article
- E-Cigarettes Increase Candida albicans Growth and Modulate its Interaction with Gingival Epithelial Cells.International journal of environmental research and public health · 2019Article
- Fungal-Host Interaction: Curcumin Modulates Proteolytic Enzyme Activity ofInternational journal of dentistry · 2018Article
- Alterations in oral microbial flora induced by waterpipe tobacco smoking.International journal of general medicine · 2018Article
- The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD.Respirology (Carlton, Vic.) · 2017Review
- cspA influences biofilm formation and drug resistance in pathogenic fungus Aspergillus fumigatus.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The predisposition of cigarette smokers for development of respiratory and oral bacterial infections is well documented. Cigarette smoke can also contribute to yeast infection. The aim of this study was to investigate the effect of cigarette smoke condensate (CSC) on C. albicans transition, chitin content, and response to environmental stress and to examine the interaction between CSC-pretreated C. albicans and normal human gingival fibroblasts. Following exposure to CSC, C. albicans transition from blastospore to hyphal form increased. CSC-pretreated yeast cells became significantly (P < 0.01) sensitive to oxidation but significantly (P < 0.01) resistant to both osmotic and heat stress. CSC-pretreated C. albicans expressed high levels of chitin, with 2- to 8-fold recorded under hyphal conditions. CSC-pretreated C. albicans adhered better to the gingival fibroblasts, proliferated almost three times more and adapted into hyphae, while the gingival fibroblasts recorded a significantly (P < 0.01) slow growth rate but a significantly higher level of IL-1β when in contact with CSC-pretreated C. albicans. CSC was thus able to modulate both C. albicans transition through the cell wall chitin content and the interaction between C. albicans and normal human gingival fibroblasts. These findings may be relevant to fungal infections in the oral cavity in smokers.
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