Trial reportBioMed research international2014
Profile of microbial keratitis after corneal collagen cross-linking.
Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Observation and assessment of the immediate use of a silicon hydrogel contact lens after transepithelial corneal cross linking: a prospective study.BMC ophthalmology · 2023Trial
- Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.Ophthalmology and therapy · 2026Review
- Insights into the clinical presentation, imaging, and management of infiltrative keratitis following accelerated corneal collagen cross-linking.Indian journal of ophthalmology · 2026Observational
- Review
- Unlocking the Yield & Quality Potential of Peppermint (M. piperita L.) for the Study of Genetic Variability Through Induced Mutagenesis.Biochemical genetics · 2026Article
- [Current aspects of vernal and atopic keratoconjunctivitis].Die Ophthalmologie · 2024Review
- Outcomes after corneal crosslinking treatment in paediatric patients with keratoconus.International ophthalmology · 2024Article
- Rates of infectious keratitis and other ocular surface adverse events in corneal cross-linking for keratoconus and corneal ectasias performed in an office-based setting: a retrospective cohort study.Eye and vision (London, England) · 2023Article
- Safety and Efficacy of Corneal Cross-Linking in Patients Affected by Keratoconus: Long-Term Results.Medical sciences (Basel, Switzerland) · 2023Article
- Current clinical practice in corneal crosslinking for treatment of progressive keratoconus in four Nordic countries.Acta ophthalmologica · 2023Article
- Acute corneal melt and perforation - A possible complication after riboflavin/UV-A crosslinking (CXL) in keratoconus.American journal of ophthalmology case reports · 2022Article
- Evaluation of a Post-Operative Therapy Protocol after Epithelium-Off Corneal Cross-Linking in Patients Affected by Keratoconus.Journal of clinical medicine · 2022Article
- Update on diagnosis and management of refractory corneal infections.Indian journal of ophthalmology · 2022Review
- The Safety Profile of FDA-Approved Epithelium-Off Corneal Cross-Linking in a US Community-Based Healthcare System.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Clinical outcomes of KeraVio using violet light: emitting glasses and riboflavin drops for corneal ectasia: a pilot study.The British journal of ophthalmology · 2021Article
- A case of infectious crystalline keratopathy after corneal cross-linking.American journal of ophthalmology case reports · 2021Article
- Infectious keratitis after corneal crosslinking for keratoconus caused by levofloxacin-resistant microorganisms.BMC ophthalmology · 2021Article
- Hypersensitivity reactions after femtosecond laser small incision lenticule extraction: a case report of corneal infiltrates.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- Article
- Bandage contact lens and topical steroids are risk factors for the development of microbial keratitis after epithelium-off CXL.BMJ open ophthalmology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo report the profile of microbial keratitis occurring after corneal collagen cross-linking (CXL) in keratoconus patients.
methodsA retrospective analysis of 2350 patients (1715 conventional CXL, 310 transepithelial CXL, and 325 accelerated CXL) over 7 years (from January 2007 to January 2014) of progressive keratoconus, who underwent CXL at a tertiary eye care centre, was performed. Clinical findings, treatment, and course of disease of four eyes that developed postprocedural moxifloxacin resistant Staphylococcus aureus (MXRSA) infectious keratitis are highlighted.
resultsFour eyes that underwent CXL (0.0017%) had corneal infiltrates. All eyes that developed keratitis had conventional CXL. Corneal infiltrates were noted on the third postoperative day. Gram's stain as well as culture reported MXRSA as the causative agent in all cases. Polymerase chain reaction (PCR) in each case was positive for eubacterial genome. All patients were treated with fortified antibiotic eye drops, following which keratitis resolved over a 6-week period with scarring. All these patients were on long-term preoperative oral/topical steroids for chronic disorders (chronic vernal keratoconjunctivitis, bronchial asthma, and chronic eczema).
conclusionThe incidence of infectious keratitis after CXL is a rare complication (0.0017%). MXRSA is a potential organism for causing post-CXL keratitis and should be identified early and treated aggressively with fortified antibiotics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.