Evidence map›Paper›PMID 25302158›Full record

ReviewPhotoacoustics2014

Sensitivity of photoacoustic microscopy.

Junjie Yao, Lihong V Wang

Abstract readReview
In one paragraph

Review in Photoacoustics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 1 synthesis or guideline pooled it.

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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Junjie YaoOptical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
Lihong V WangOptical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

Funding

PHOTON TUNNELING: SHEDDING NEW LIGHT ON BIOMEDICINEDP1EB016986 · NIBIB · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2012 to 2016
$3.8M
IN VIVO IMAGING OF SINGLE CIRCULATING CELLSR01CA186567 · NCI · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2013 to 2017
$3.6M
PHOTOACOUSTIC MICROSCOPY OF NEOVASCULARIZATION IN RENAL CANCER GROWTH AND THERAPYR01CA159959 · NCI · WASHINGTON UNIVERSITY · PI ARBEIT, JEFFREY MICHAEL · 2011 to 2015
$2.9M
Monitoring of Breast Neoadjuvant Therapy by Thermo- and Photo- Acoustic TomographR01CA134539 · NCI · WASHINGTON UNIVERSITY · PI MONSEES, BARBARA, WANG, LIHONG · 2009 to 2013
$2.9M
Photoacoustic endoscopy of Barretts esophagusR01CA157277 · NCI · WASHINGTON UNIVERSITY · PI MEYERS, BRYAN F, ZHOU, QIFA · 2010 to 2014
$2.7M
WHOLE-BODY SMALL-ANIMAL PHOTOACOUSTIC-ULTRASONIC COMPUTED TOMOGRAPHYR01EB016963 · NIBIB · WASHINGTON UNIVERSITY · PI ANASTASIO, MARK A · 2013 to 2016
$2.4M
Development of Thermoacoustic Tomography Brain ImagingR01EB010049 · NIBIB · WASHINGTON UNIVERSITY · PI ANASTASIO, MARK A · 2010 to 2013
$1.6M
NCI NIH HHS R01 CA134539NCI NIH HHS R01 CA157277NCI NIH HHS R01 CA159959NCI NIH HHS R01 CA186567NIBIB NIH HHS DP1 EB016986NIBIB NIH HHS R01 EB010049NIBIB NIH HHS R01 EB016963
6 · The paper itself

Abstract

Building on its high spatial resolution, deep penetration depth and excellent image contrast, 3D photoacoustic microscopy (PAM) has grown tremendously since its first publication in 2005. Integrating optical excitation and acoustic detection, PAM has broken through both the optical diffusion and optical diffraction limits. PAM has 100% relative sensitivity to optical absorption (i.e., a given percentage change in the optical absorption coefficient yields the same percentage change in the photoacoustic amplitude), and its ultimate detection sensitivity is limited only by thermal noise. Focusing on the engineering aspects of PAM, this Review discusses the detection sensitivity of PAM, compares the detection efficiency of different PAM designs, and summarizes the imaging performance of various endogenous and exogenous contrast agents. It then describes representative PAM applications with high detection sensitivity, and outlines paths to further improvement.

Indexed as

Absorption contrastContrast agentsDetection sensitivityEarly cancer detectionPhotoacoustic microscopyUltrasonic transducer

Identifiers

PMID25302158
PMCPMC4182819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.