ArticleNutrition & metabolism2014
The effect of the macrobiotic Ma-Pi 2 diet vs. the recommended diet in the management of type 2 diabetes: the randomized controlled MADIAB trial.
Article in Nutrition & metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The Effect of Prebiotics and Oral Anti-Diabetic Agents on Gut Microbiome in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials.Nutrients · 2022 · on this mapPooled it
- Pooled it
- Pooled it
- Systematic review assessing the effectiveness of dietary intervention on gut microbiota in adults with type 2 diabetes.Diabetologia · 2018Pooled it
- Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial.Diabetes/metabolism research and reviews · 2025Trial
- Increased sclerostin and bone turnover after diet-induced weight loss in type 2 diabetes: a post hoc analysis of the MADIAB trial.Endocrine · 2017Trial
- High-fiber diet reduces bone formation but does not affect bone microarchitecture in type 2 diabetes individuals.JBMR plus · 2024Article
- The Global Burden of Vascular Intestinal Disorders in 204 Countries and Territories From 1990 to 2019: Global Burden of Diseases Study.International journal of public health · 2023Article
- The Impact of Diet on Bone and Fracture Risk in Diabetes.Current osteoporosis reports · 2022Review
- High-Fiber Diet or Combined With Acarbose Alleviates Heterogeneous Phenotypes of Polycystic Ovary Syndrome by Regulating Gut Microbiota.Frontiers in endocrinology · 2021Article
- Changes in intestinal flora in patients with type 2 diabetes on a low-fat diet during 6 months of follow-up.Experimental and therapeutic medicine · 2020Article
- Nutritional Modulation of the Microbiome and Immune Response.Journal of immunology (Baltimore, Md. : 1950) · 2020Review
- Long-Term Vegan Meditation Improved Human Gut Microbiota.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- The association between dietary fibre deficiency and high-income lifestyle-associated diseases: Burkitt's hypothesis revisited.The lancet. Gastroenterology & hepatology · 2019Review
- [Nutrition in type 2 diabetes mellitus].Der Internist · 2019Article
- Diet Composition for the Management of Obesity and Obesity-related Disorders.Journal of diabetes mellitus and metabolic syndrome · 2018Article
- Effectiveness of plant-based diets in promoting well-being in the management of type 2 diabetes: a systematic review.BMJ open diabetes research & care · 2018Article
- Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes.Nutrients · 2017Review
- A 6-month follow-up study of the randomized controlled Ma-Pi macrobiotic dietary intervention (MADIAB trial) in type 2 diabetes.Nutrition & diabetes · 2016Article
- Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet.The British journal of nutrition · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiet is an important component of type 2 diabetes therapy. Low adherence to current therapeutic diets points out to the need for alternative dietary approaches. This study evaluated the effect of a different dietary approach, the macrobiotic Ma-Pi 2 diet, and compared it with standard diets recommended for patients with type 2 diabetes.
methodsA randomized, controlled, open-label, 21-day trial was undertaken in patients with type 2 diabetes comparing the Ma-Pi 2 diet with standard (control) diet recommended by professional societies for treatment of type 2 diabetes. Changes in fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) were primary outcomes. HbA1c, insulin resistance (IR), lipid panel and anthropometrics were secondary outcomes.
resultsAfter correcting for age, gender, BMI at baseline, and physical activity, there was a significantly greater reduction in the primary outcomes FBG (95% CI: 1.79; 13.46) and PPBG (95% CI: 5.39; 31.44) in those patients receiving the Ma-Pi 2 diet compared with those receiving the control diet. Statistically significantly greater reductions in the secondary outcomes, HbA1c (95% CI: 1.28; 5.46), insulin resistance, total cholesterol, LDL cholesterol and LDL/HDL ratio, BMI, body weight, waist and hip circumference were also found in the Ma-Pi 2 diet group compared with the control diet group. The latter group had a significantly greater reduction of triglycerides compared with the Ma-Pi 2 diet group.
conclusionsIntervention with a short-term Ma-Pi 2 diet resulted in significantly greater improvements in metabolic control in patients with type 2 diabetes compared with intervention with standard diets recommended for these patients.
trial registrationCurrent Controlled Trials ISRCTN10467793.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.