Evidence map›Paper›PMID 25301934›Full record

ReviewCold Spring Harbor perspectives in medicine2014

Role of B cells and antibodies in acquired immunity against Mycobacterium tuberculosis.

Jacqueline M Achkar, John Chan, Arturo Casadevall

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Predicted Structural Variability ofFrontiers in microbiology · 2020
    Article
  14. Review
  15. Review
  16. Article
  17. Association of Immune Factors with Drug-Resistant Tuberculosis: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  18. Article
  19. Antibodies and tuberculosis.Tuberculosis (Edinburgh, Scotland) · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jacqueline M AchkarDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
John ChanDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461 Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Arturo CasadevallDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461 Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Albert Einstein College of Medicine · US

Funding

Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI GOLDSTEIN, HARRIS · 2003 to 2013
$18.6M
"The Tuberculous Granuloma"P01AI063537 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI JACOBS, WILLIAM ROBERT · 2005 to 2015
$15.7M
Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONSR01AI033774 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2014
$5.6M
Molecular Characterization of C. neoformans AntibodiesR37AI033142 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2007 to 2016
$3.9M
B cells and humoral immunity in tuberculosisR01AI094745 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHAN, JOHN R. · 2012 to 2016
$3.2M
MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIESR01AI033142 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2006
$1.7M
Discovery of Biological and Immunological Biomarkers for TB VaccinesU18FD004012 · FDA · AERAS · PI BRENNAN, MICHAEL · 2010 to 2012
$853k
Immunodiagnostic Tests for the Rapid Diagnosis of TbK23AI067665 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ACHKAR, JACQUELINE MICHELE · 2007 to 2011
$666k
Novel serological biomarker for rapid tuberculosis diagnosisR21AI105684 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ACHKAR, JACQUELINE MICHELE · 2013 to 2014
$444k
FDA HHS 1U18 FD004012/01FDA HHS U18 FD004012NHLBI NIH HHS HL-059842NHLBI NIH HHS R01 HL059842NIAID NIH HHS AI-033142NIAID NIH HHS AI-033774NIAID NIH HHS AI-052733NIAID NIH HHS AI063537NIAID NIH HHS AI-067665NIAID NIH HHS AI094745NIAID NIH HHS AI-105684NIAID NIH HHS AI-51519NIAID NIH HHS K23 AI067665NIAID NIH HHS P01 AI063537NIAID NIH HHS P30 AI051519NIAID NIH HHS R01 AI033142NIAID NIH HHS R01 AI033774NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI094745NIAID NIH HHS R21 AI105684NIAID NIH HHS R37 AI033142
6 · The paper itself

Abstract

Accumulating evidence has documented a role for B cells and antibodies (Abs) in the immunity against Mycobacterium tuberculosis (Mtb). Passive transfer studies with monoclonal antibodies (mAbs) against mycobacterial antigens have shown protection against the tubercle bacillus. B cells and Abs are believed to contribute to an enhanced immune response against Mtb by modulating various immunological components in the infected host including the T-cell compartment. Nevertheless, the extent and contribution of B cells and Abs to protection against Mtb remains uncertain. In this article we summarize the most relevant findings supporting the role of B cells and Abs in the defense against Mtb and discuss the potential mechanisms of protection.

Indexed as

AnimalsAntibodies, BacterialAntibodies, MonoclonalB-LymphocytesHumansImmunity, CellularImmunity, HumoralMacrophagesMiceMycobacterium tuberculosisT-LymphocytesTuberculosis VaccinesAntibodies, BacterialAntibodies, MonoclonalTuberculosis Vaccines

Identifiers

PMID25301934
PMCPMC4355258
OpenAlexW2125568747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.