Evidence map›Paper›PMID 25301812›Full record

ReviewNeuro-oncology2015

Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.

Jakub Godlewski, Anna M Krichevsky, Mark D Johnson, E Antonio Chiocca, Agnieszka Bronisz

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jakub GodlewskiDepartment of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
Anna M KrichevskyDepartment of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
Mark D JohnsonDepartment of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
E Antonio ChioccaDepartment of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
Agnieszka BroniszDepartment of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
Harvard University · US

Funding

The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAREST, ALAIN · 1996 to 2021
$30.9M
Transfer of microRNA regulators from glioblastoma to brain microenvironment U19CA179563 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, CHAREST, ALAIN · 2013 to 2017
$8.6M
MicroRNA128 Regulation of Polycomb Repressor Complexes1 and 2 in GlioblastomaR01CA176203 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GODLEWSKI, JAKUB · 2014 to 2018
$1.8M
Validation of microRNA Targets in GliomaR01CA138734 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI KRICHEVSKY, ANNA M. · 2010 to 2014
$1.7M
NCI NIH HHS 1R01CA176203-01A1NCI NIH HHS 5P01CA069246-16NCI NIH HHS P01 CA069246NCI NIH HHS R01 CA138734NCI NIH HHS R01CA138734NCI NIH HHS R01 CA176203NCI NIH HHS U19 CA179563NCI NIH HHS U19 CA179563-01
6 · The paper itself

Abstract

The complexity of glioblastoma multiforme (GBM) and its distinct pathophysiology belong to a unique brain microenvironment and its cellular interactions. Despite extensive evidence of a role for microRNAs in GBM cells, little is known about microRNA-dependent communication between different cellular compartments of the microenvironment that may contribute to the tumor phenotype. While the majority of microRNAs are found intracellularly, a significant number of microRNAs have been observed outside of cells, often encapsulated in secreted extracellular vesicles (EVs). The function of these circulating/secreted microRNAs has not been explored in the context of the brain tumor microenvironment. Establishing how microRNAs are involved in the regulation of oncogenic signaling networks between tumor cells and stroma is likely to add a needed additional layer of complexity to the tumor network, consisting of intercellular communication. More importantly, microRNA/EV signaling may provide an additional therapeutic target for this deadly disease.

Indexed as

Tumor MicroenvironmentAnimalsBrain NeoplasmsExosomesGlioblastomaHumansMicroRNAsSignal TransductionMicroRNAsexosomesextracellular vesiclesglioblastoma multiformemicroRNAtumor microenvironment

Identifiers

PMID25301812
PMCPMC4482852
OpenAlexW2126948899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.