ArticleBMC pediatrics2014
Abdominal obesity and low physical activity are associated with insulin resistance in overweight adolescents: a cross-sectional study.
Article in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Screen time increases overweight and obesity risk among adolescents: a systematic review and dose-response meta-analysis.BMC primary care · 2022Pooled it
- Changes in objectively measured physical activity after a multidisciplinary lifestyle intervention in children with abdominal obesity: a randomized control trial.BMC pediatrics · 2019Trial
- Central obesity is a burden even in normal weight adolescents of a non-metropolitan Indian City: A case for alarm and action for prevention and control.Journal of family medicine and primary care · 2025Article
- Using the RE-AIM framework to evaluate the feasibility of a parent-focused intervention targeting childhood obesity.Pilot and feasibility studies · 2023Article
- Sociodemographic inequalities in cardiovascular risk factors among adolescents from indigenous areas in Chiapas, Mexico.Cadernos de saude publica · 2023Article
- The Influence of Abdominal Adiposity and Physical Fitness on Obesity Status of Portuguese Adolescents.International journal of environmental research and public health · 2022Article
- Simple Method to Predict Insulin Resistance in Children Aged 6-12 Years by Using Machine Learning.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise.International journal of environmental research and public health · 2021Review
- The Prevalence of Insulin Resistance and the Associated Risk Factors in a Sample of 14-18-Year-Old Slovak Adolescents.International journal of environmental research and public health · 2021Article
- Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence.Journal of diabetes research · 2021Review
- Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue-A Key to Explaining the Obesity Paradox.International journal of environmental research and public health · 2020Article
- Prevalence and Determinants of Hypertension Among Diabetic Patients in Jimma University Medical Center, Southwest Ethiopia, 2019.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Dietary Intake and Physical Activity in Relation to Insulin Resistance in Young Overweight Saudi Females: An Exploratory Pilot Study.Preventive nutrition and food science · 2019Article
- Assessment of anthropometric indices other than BMI to evaluate arterial stiffness.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Participants' Perceptions of "C.H.A.M.P. Families": A Parent-Focused Intervention Targeting Paediatric Overweight and Obesity.International journal of environmental research and public health · 2019Article
- Differential effects of age and sex on insulin sensitivity and body composition in adolescent offspring of women with type 1 diabetes: results from the EPICOM study.Diabetologia · 2018Article
- Adolescent's Health Behaviors and Risk for Insulin Resistance: A Review of the Literature.Current diabetes reports · 2017Review
- Physical Activity and Risk of Colon Cancer in Diabetic and Nondiabetic US Adults.Mayo Clinic proceedings · 2016Article
- Obesity and Hypertension among School-going Adolescents in Peru.Journal of lifestyle medicine · 2015Article
- High prevalence and clustering of modifiable CVD risk factors among rural adolescents in southwest Nigeria: implication for grass root prevention.BMC public health · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have assessed the metabolic changes and lifestyles associated with overweight adolescents. However, these associations are unclear amongst overweight adolescents who have already developed insulin resistance. This study assessed the associations between insulin resistance and anthropometric, metabolic, inflammatory, food consumption, and physical activity variables amongst overweight adolescents.
methodsThis cross-sectional study divided adolescents (n = 120) between 10 and 18 years old into 3 groups: an overweight group with insulin resistance (O + IR), an overweight group without insulin resistance (O-IR), and a normal-weight control group (NW). Adolescents were matched across groups based on age, sex, pubertal maturation, and socioeconomic strata. Anthropometric, biochemical, physical activity, and food consumption variables were assessed. Insulin resistance was assessed using homeostatic model assessment (HOMA Calculator Version 2.2.2 from ©Diabetes Trials Unit, University of Oxford), and overweight status was assessed using body mass index according to World Health Organization (2007) references. A chi-square test was used to compare categorical variables. ANOVAs or Kruskal-Wallis tests were used for continuous variables. Multiple linear regression models were used to calculate the probability of the occurrence of insulin resistance based on the independent variables.
resultsThe risk of insulin resistance amongst overweight adolescents increases significantly when they reach a waist circumference > p95 (OR = 1.9, CIs = 1.3-2.7, p = 0.013) and watch 3 or more hours/day of television (OR = 1.7, CIs = 0.98-2.8, p = 0.033). Overweight status and insulin resistance were associated with higher levels of inflammation (hsCRP ≥1 mg/L) and cardiovascular risk according to arterial indices. With each cm increase in waist circumference, the HOMA index increased by 0.082; with each metabolic equivalent (MET) unit increase in physical activity, the HOMA index decreased by 0.026.
conclusionsSedentary behaviour and a waist circumference > p90 amongst overweight adolescents were associated with insulin resistance, lipid profile alterations, and higher inflammatory states. A screening that includes body mass index, in waist circumference, and physical activity evaluations of adolescents might enable the early detection of these alterations.
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