ArticleBMC genomics2014
Divergence of RNA localization between rat and mouse neurons reveals the potential for rapid brain evolution.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Antithetical roles of tau in hippocampal long-term synaptic depression in rats versus mice.Molecular brain · 2026Article
- Mapping Brain Spatial Metabolic Atlas Reveals Anesthesia-Induced Region-Specific Alterations.Neuroscience bulletin · 2026Article
- Animal models in neuroscience with alternative approaches: Evolutionary, biomedical, and ethical perspectives.Animal models and experimental medicine · 2024Review
- Article
- Review
- Quantitative Measurement of Tau Aggregation in Genetically Modified Rats with Neurodegeneration.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain.Brain : a journal of neurology · 2022Article
- Article
- Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations.NMR in biomedicine · 2020Article
- Folate-Dependent Cognitive Impairment Associated With Specific Gene Networks in the Adult Mouse Hippocampus.Frontiers in nutrition · 2020Article
- Comprehensive catalog of dendritically localized mRNA isoforms from sub-cellular sequencing of single mouse neurons.BMC biology · 2019Article
- Single-cell nanobiopsy reveals compartmentalization of mRNAs within neuronal cells.The Journal of biological chemistry · 2018Article
- Electroacupuncture preconditioning protects against focal cerebral ischemia/reperfusion injuryNeural regeneration research · 2018Article
- Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11).Toxics · 2017Article
- Novel application of a Radial Water Tread maze can distinguish cognitive deficits in mice with traumatic brain injury.Brain research · 2017Article
- Rodent models in neuroscience research: is it a rat race?Disease models & mechanisms · 2016Review
- Differences in Akt signaling and metabolism gene expression in the right heart, intraventricular septum and left heart of rodents.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeurons display a highly polarized architecture. Their ability to modify their features under intracellular and extracellular stimuli, known as synaptic plasticity, is a key component of the neurochemical basis of learning and memory. A key feature of synaptic plasticity involves the delivery of mRNAs to distinct sub-cellular domains where they are locally translated. Regulatory coordination of these spatio-temporal events is critical for synaptogenesis and synaptic plasticity as defects in these processes can lead to neurological diseases. In this work, using microdissected dendrites from primary cultures of hippocampal neurons of two mouse strains (C57BL/6 and Balb/c) and one rat strain (Sprague-Dawley), we investigate via microarrays, subcellular localization of mRNAs in dendrites of neurons to assay the evolutionary differences in subcellular dendritic transcripts localization.
resultsOur microarray analysis highlighted significantly greater evolutionary diversification of RNA localization in the dendritic transcriptomes (81% gene identity difference among the top 5% highly expressed genes) compared to the transcriptomes of 11 different central nervous system (CNS) and non-CNS tissues (average of 44% gene identity difference among the top 5% highly expressed genes). Differentially localized genes include many genes involved in CNS function.
conclusionsSpecies differences in sub-cellular localization may reflect non-functional neutral drift. However, the functional categories of mRNA showing differential localization suggest that at least part of the divergence may reflect activity-dependent functional differences of neurons, mediated by species-specific RNA subcellular localization mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.