ArticlePsychopharmacology2015
Dopaminergic modulation of distracter-resistance and prefrontal delay period signal.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task.Psychopharmacology · 2022Trial
- Effects of tolcapone and bromocriptine on cognitive stability and flexibility.Psychopharmacology · 2018Trial
- Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment - a randomized double-blind placebo-controlled trial.Human psychopharmacology · 2016Trial
- Striatal dopamine can enhance both fast working memory, and slow reinforcement learning, while reducing implicit effort cost sensitivity.Nature communications · 2025Article
- Signal Intrusion Explains Divergent Effects of Visual Distraction on Working Memory.Psychological science · 2025Article
- A dopaminergic basis of behavioral control.bioRxiv : the preprint server for biology · 2024Article
- Dynamic Network Connectivity: from monkeys to humans.Frontiers in human neuroscience · 2024Review
- Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning.Nature communications · 2022Article
- Molecular Imaging of Central Dopamine in Obesity: A Qualitative Review across Substrates and Radiotracers.Brain sciences · 2022Review
- Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia.Nature communications · 2021Article
- Distraction in Visual Working Memory: Resistance is Not Futile.Trends in cognitive sciences · 2021Review
- Dynamic functional connectivity between nucleus accumbens and the central executive network relates to chronic cannabis use.Human brain mapping · 2020Article
- Association Between Duration of Untreated Psychosis and Frontostriatal Connectivity During Maintenance of Visuospatial Working Memory.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Dopamine affects short-term memory corruption over time in Parkinson's disease.NPJ Parkinson's disease · 2019Article
- Effects of Parkinson's disease and dopamine on digit span measures of working memory.Psychopharmacology · 2018Article
- Ignoring versus updating in working memory reveal differential roles of attention and feature binding.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Interactions of Motivation and Cognitive Control.Current opinion in behavioral sciences · 2018Article
- Dopamine Alters the Fidelity of Working Memory Representations according to Attentional Demands.Journal of cognitive neuroscience · 2017Article
- Causes and consequences of limitations in visual working memory.Annals of the New York Academy of Sciences · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Dopamine has long been implicated in the online maintenance of information across short delays. Specifically, dopamine has been proposed to modulate the strength of working memory representations in the face of intervening distracters. This hypothesis has not been tested in humans. We fill this gap using pharmacological neuroimaging. Healthy young subjects were scanned after intake of the dopamine receptor agonist bromocriptine or placebo (in a within-subject, counterbalanced, and double-blind design). During scanning, subjects performed a delayed match-to-sample task with face stimuli. A face or scene distracter was presented during the delay period (between the cue and the probe). Bromocriptine altered distracter-resistance, such that it impaired performance after face relative to scene distraction. Individual differences in the drug effect on distracter-resistance correlated negatively with drug effects on delay period signal in the prefrontal cortex, as well as on functional connectivity between the prefrontal cortex and the fusiform face area. These results provide evidence for the hypothesis that dopaminergic modulation of the prefrontal cortex alters resistance of working memory representations to distraction. Moreover, we show that the effects of dopamine on the distracter-resistance of these representations are accompanied by modulation of the functional strength of connections between the prefrontal cortex and stimulus-specific posterior cortex.
Indexed as
Identifiers
25300902What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.