ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2014
Cerenkov luminescence endoscopy: improved molecular sensitivity with β--emitting radiotracers.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Practical Guidance for Developing Small-Molecule Optical Probes for In Vivo Imaging.Molecular imaging and biology · 2023Review
- Detection of Shortwave-Infrared Cerenkov Luminescence from Medical Isotopes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Sensitivity improved Cerenkov luminescence endoscopy using optimal system parameters.Quantitative imaging in medicine and surgery · 2022Article
- Radioluminescence in biomedicine: physics, applications, and models.Physics in medicine and biology · 2019Review
- Enhanced Cerenkov luminescence tomography analysis based on YBiomedical optics express · 2018Article
- Cerenkov-Activated Sticky Tag for In Vivo Fluorescence Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- Cerenkov luminescence imaging: physics principles and potential applications in biomedical sciences.EJNMMI physics · 2017Review
- Quantitative Measurement of the Thyroid Uptake Function of Mouse by Cerenkov Luminescence Imaging.Scientific reports · 2017Article
- Intratumoral treatment with radioactive beta-emitting microparticles: a systematic review.Journal of radiation oncology · 2017Review
- Optical Imaging of Ionizing Radiation from Clinical Sources.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Review
- Article
- Hybrid Light Imaging Using Cerenkov Luminescence and Liquid Scintillation for Preclinical Optical Imaging In Vivo.Molecular imaging and biology · 2016Article
- Cerenkov luminescence imaging (CLI) for image-guided cancer surgery.Clinical and translational imaging · 2016Review
- Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications.Physics in medicine and biology · 2015Article
- Cerenkov Luminescence Imaging for Radiation Dose Calculation of a ⁹⁰Y-Labeled Gastrin-Releasing Peptide Receptor Antagonist.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
unlabelledCerenkov luminescence endoscopy (CLE) is an optical technique that captures the Cerenkov photons emitted from highly energetic moving charged particles (β(+) or β(-)) and can be used to monitor the distribution of many clinically available radioactive probes. A main limitation of CLE is its limited sensitivity to small concentrations of radiotracer, especially when used with a light guide. We investigated the improvement in the sensitivity of CLE brought about by using a β(-) radiotracer that improved Cerenkov signal due to both higher β-particle energy and lower γ noise in the imaging optics because of the lack of positron annihilation.
methodsThe signal-to-noise ratio (SNR) of (90)Y was compared with that of (18)F in both phantoms and small-animal tumor models. Sensitivity and noise characteristics were demonstrated using vials of activity both at the surface and beneath 1 cm of tissue. Rodent U87MG glioma xenograft models were imaged with radiotracers bound to arginine-glycine-aspartate (RGD) peptides to determine the SNR.
resultsγ noise from (18)F was demonstrated by both an observed blurring across the field of view and a more pronounced fall-off with distance. A decreased γ background and increased energy of the β particles resulted in a 207-fold improvement in the sensitivity of (90)Y compared with (18)F in phantoms. (90)Y-bound RGD peptide produced a higher tumor-to-background SNR than (18)F in a mouse model.
conclusionThe use of (90)Y for Cerenkov endoscopic imaging enabled superior results compared with an (18)F radiotracer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.