ArticleDevelopmental biology2014
Hedgehog activity controls opening of the primary mouth.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Reciprocal E-cadherin signaling aligns apical surfaces between neighboring epithelial tissues to complete the C. elegans digestive tract.Current biology : CB · 2026Article
- The metamorphic transition of the frog mouth: from tadpole keratinized mouthparts to adult teeth.Royal Society open science · 2025Article
- Pituitary Gland Duplication Syndrome: An International Imaging Analysis.AJNR. American journal of neuroradiology · 2025Article
- Small Molecules Promote the Rapid Generation of Dental Epithelial Cells from Human-Induced Pluripotent Stem Cells.International journal of molecular sciences · 2024Article
- The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development.Journal of anatomy · 2024Article
- Jak2 and Jaw Muscles Are Required for Buccopharyngeal Membrane Perforation during Mouth Development.Journal of developmental biology · 2023Article
- Won't You be My Neighbor: How Epithelial Cells Connect Together to Build Global Tissue Polarity.Frontiers in cell and developmental biology · 2022Review
- Hedgehog signaling controls mouth opening in the amphioxus.Zoological letters · 2021Article
- Nutrient availability contributes to a graded refractory period for regeneration in Xenopus tropicalis.Developmental biology · 2021Article
- Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development inFrontiers in physiology · 2019Article
- Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond.International journal of molecular sciences · 2018Review
- Mouth development.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Smoothened is a poor prognosis factor and a potential therapeutic target in glioma.Scientific reports · 2017Article
- Conserved and novel functions of programmed cellular senescence during vertebrate development.Development (Cambridge, England) · 2017Article
- Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling.Cell reports · 2016Article
- Using frogs faces to dissect the mechanisms underlying human orofacial defects.Seminars in cell & developmental biology · 2016Review
- Dynamic epithelia of the developing vertebrate face.Current opinion in genetics & development · 2015Review
- Sonic hedgehog signaling in craniofacial development.Differentiation; research in biological diversityReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
To feed or breathe, the oral opening must connect with the gut. The foregut and oral tissues converge at the primary mouth, forming the buccopharyngeal membrane (BPM), a bilayer epithelium. Failure to form the opening between gut and mouth has significant ramifications, and many craniofacial disorders have been associated with defects in this process. Oral perforation is characterized by dissolution of the BPM, but little is known about this process. In humans, failure to form a continuous mouth opening is associated with mutations in Hedgehog (Hh) pathway members; however, the role of Hh in primary mouth development is untested. Here, we show, using Xenopus, that Hh signaling is necessary and sufficient to initiate mouth formation, and that Hh activation is required in a dose-dependent fashion to determine the size of the mouth. This activity lies upstream of the previously demonstrated role for Wnt signal inhibition in oral perforation. We then turn to mouse mutants to establish that SHH and Gli3 are indeed necessary for mammalian mouth development. Our data suggest that Hh-mediated BPM persistence may underlie oral defects in human craniofacial syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.