Evidence map›Paper›PMID 25300404›Full record

ArticleDementia and geriatric cognitive disorders2015

Longitudinal declines in instrumental activities of daily living in stable and progressive mild cognitive impairment.

Julia J Hsiao, Po H Lu, Joshua D Grill, Edmond Teng

Abstract read
In one paragraph

Article in Dementia and geriatric cognitive disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Brain amyloid, cortical thickness, and changes in activities of daily living.Annals of clinical and translational neurology · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Julia J HsiaoDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Calif., USA.
Po H Lu
Joshua D Grill
Edmond Teng

Funding

NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VINTERS, HARRY V. · 1999 to 2014
$25.9M
Biological Underpinnings and Cognitive Expression of Brain AgingK23AG028727 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LU, PO · 2008 to 2012
$839k
Assessment of Biomarkers and Behavior in a Transgenic Rat Model of ADK08AG034628 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TENG, EDMOND HUATUNG · 2009 to 2013
$540k
NIA NIH HHS K08 AG034628NIA NIH HHS K08 AG34628NIA NIH HHS K23 AG028727NIA NIH HHS P50 AG016570NIA NIH HHS P50 AG16570NIA NIH HHS U01 AG016976
6 · The paper itself

Abstract

backgroundPrevious cross-sectional studies suggest that assessments of instrumental activities of daily living (IADLs) may be useful for operationalizing the differences in functional deficits seen in mild cognitive impairment (MCI) and dementia. However, their utility for longitudinal changes in IADLs in the transition between MCI and dementia remains unclear.

methodsWe analyzed longitudinal IADL data with the Functional Activities Questionnaire (FAQ) in stable (MCI-S; n = 1,318) or progressive (MCI-P; n = 1,108) MCI patients.

resultsLarger increases in FAQ scores were seen in the MCI-P group across a 14.5-month interval, but overlapping distributions in the two groups yielded poorer discriminatory power than prior cross-sectional reports.

conclusionOur findings emphasize the difficulties in operationalizing the criterion of 'essentially intact' IADLs in MCI, which may complicate the interpretation of disease progression in MCI treatment trials.

Indexed as

Activities of Daily LivingAgedAlzheimer DiseaseAmnesiaCase-Control StudiesCognitive DysfunctionCross-Sectional StudiesDisability EvaluationDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedSurveys and Questionnaires

Identifiers

PMID25300404
PMCPMC4312538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.