ArticleJournal of neural transmission (Vienna, Austria : 1996)2015
Neuronal nitric oxide synthase (nNOS, NOS1) rs693534 and rs7977109 variants and risk for restless legs syndrome.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Restless legs syndrome and inflammatory bowel disease: A systematic review and meta-analysis.IBRO neuroscience reports · 2025Article
- Residual periodic limb movement index after CPAP therapy is associated with hypoxemia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
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- Serum vitamin D, vitamin D receptor and binding protein genes polymorphisms in restless legs syndrome.Journal of neurology · 2021Article
- Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome.Frontiers in pharmacology · 2021Article
- Unraveling the Mysteries of Restless Leg Syndrome.Cureus · 2020Review
- Potential Therapeutic Role of Dietary Supplementation withOxidative medicine and cellular longevity · 2020Article
- The molecular genetics of human sleep.The European journal of neuroscience · 2020Article
- Impaired endothelial function may predict treatment response in restless legs syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- IL1B polymorphism is associated with essential tremor in Chinese population.BMC neurology · 2019Article
- Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome.The pharmacogenomics journal · 2018Article
- A Genome-Wide Association Study IdentifiesPsychiatry investigation · 2017Article
- Iron and restless legs syndrome: treatment, genetics and pathophysiology.Sleep medicine · 2017Article
- Pleiotropic genetic effects influencing sleep and neurological disorders.The Lancet. Neurology · 2017Review
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Authors and funding
18 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several biochemical, neuropathological, and experimental data suggest a possible role of nitric oxide (NO) in the pathophysiology of restless legs syndrome (RLS). Two single nucleotide polymorphisms (SNPs) neuronal nitric oxide synthase (nNOS or NOS1) gene (rs7977109 and rs693534) have been found to be associated with the risk for RLS in Germans, although only one of them (rs7977109) remained as significant after multiple comparison tests. The aim of our study was to replicate the possible association between these SNPs and risk for RLS in the Spanish population. We studied the allelic and genotype frequencies of the SNPs rs7977109 and rs693534 in 205 patients with RLS and 328 healthy controls using TaqMan genotyping. The rs7977109 and rs693534 genotypes and allelic frequencies did not significantly differ between patients with RLS and controls and were unrelated with the age at onset of RLS, gender, ferritin levels, and response to dopaminergic or gabaergic agents. The rs7999109GA genotype was overrepresented in RLS patients with positive family history of RLS, and in patients with symptomatic response to clonazepam. The results of our study suggest that these two NOS1 SNPs are not related to the overall risk for RLS in the Spanish population.
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