Trial reportJournal of Huntington's disease2014
Improved Executive Function and Callosal White Matter Microstructure after Rhythm Exercise in Huntington's Disease.
Trial report in Journal of Huntington's disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Cognition-oriented treatments and physical exercise on cognitive function in Huntington's disease: a systematic review.Journal of neurology · 2023Pooled it
- Therapeutic Use of Music, Dance, and Rhythmic Auditory Cueing for Patients with Huntington's Disease: A Systematic Review.Journal of Huntington's disease · 2019Pooled it
- A Review of the Clinical Evidence for Complementary and Alternative Medicine in Huntington's Disease.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Article
- Effects and mechanisms of computerized cognitive training in Huntington's disease: protocol for a pilot study.Neurodegenerative disease management · 2024Article
- Sensorimotor Impairment in Aging and Neurocognitive Disorders: Beat Synchronization and Adaptation to Tempo Changes.Journal of Alzheimer's disease : JAD · 2024Article
- The Role of Innovation Technology in the Rehabilitation of Patients Affected by Huntington's Disease: A Scoping Review.Biomedicines · 2023Article
- HD-DRUM, a Tablet-Based Drumming Training App Intervention for People With Huntington Disease: App Development Study.JMIR formative research · 2023Article
- Treatments and regulatory mechanisms of acoustic stimuli on mood disorders and neurological diseases.Frontiers in neuroscience · 2023Review
- Physical activity and the brain myelin content in humans.Frontiers in cellular neuroscience · 2023Review
- Mutation-related magnetization-transfer, not axon density, drives white matter differences in premanifest Huntington disease: Evidence from in vivo ultra-strong gradient MRI.Human brain mapping · 2022Article
- Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis.Ageing research reviews · 2021Review
- Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease.GeroScience · 2020Review
- Drumming Motor Sequence Training Induces Apparent Myelin Remodelling in Huntington's Disease: A Longitudinal Diffusion MRI and Quantitative Magnetization Transfer Study.Journal of Huntington's disease · 2020Article
- Myelin Breakdown in Human Huntington's Disease: Multi-Modal Evidence from Diffusion MRI and Quantitative Magnetization Transfer.Neuroscience · 2019Article
- International Guidelines for the Treatment of Huntington's Disease.Frontiers in neurology · 2019Article
- The Effects of Bimanual Coordination in Music Interventions on Executive Functions in Aging Adults.Frontiers in integrative neuroscience · 2019Article
- Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study.Pilot and feasibility studies · 2018Article
- All Wrapped Up: Environmental Effects on Myelination.Trends in neurosciences · 2017Review
- Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease.Human molecular genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHuntington's disease (HD) is an autosominal dominant neurodegenerative condition that leads to progressive loss of motor and cognitive functions. Early symptoms in HD include subtle executive dysfunction related to white and grey matter loss in cortico-striatal-thalamic loops. There is no cure for HD and hence a significant need for early intervention with the potential to delay the clinical onset of the disease.
objectiveThe objective of the present pilot study was to devise a novel behavioural intervention involving drumming and rhythm exercises that targets early dysexecutive problems, such as difficulties in sequence and reversal learning, response speed, timing, and dual tasking.
methodOne preclinical person and nine people with early to advanced stages of HD were recruited of whom five completed the two months intervention. The effects of rhythm exercise on executive function, basal ganglia volume, and white matter microstructure in the anterior corpus callosum, the anterior thalamic radiation, and the cortico-spinal tract were assessed post- relative to pre-training.
resultsAfter two months training, improvements in executive function and changes in white matter microstructure, notably in the genu of the corpus callosum that connects prefrontal cortices of both hemispheres, were observed. No changes in basal ganglia volume were present.
conclusionThis pilot study provides novel preliminary evidence that carefully targeted behavioural stimulation in HD can result in cognitive enhancement and improvements in callosal white matter microstructure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.