ArticleSensors (Basel, Switzerland)2014
Correlation of X-ray computed tomography with quantitative nuclear magnetic resonance methods for pre-clinical measurement of adipose and lean tissues in living mice.
Article in Sensors (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
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- Effects of Overexpression of Fibroblast Growth Factor 15/19 on Hepatic Drug Metabolizing Enzymes.Drug metabolism and disposition: the biological fate of chemicals · 2022Article
- Sex-dependent effects of forced exercise in the body composition of adolescent rats.Scientific reports · 2021Article
- Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD.Journal of translational medicine · 2021Article
- Article
- Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis.Brain communications · 2020Article
- Evaluation of Hepatic Steatosis in Rodents by Time-Domain Nuclear Magnetic Resonance.Diagnostics (Basel, Switzerland) · 2019Article
- Normalizing Plasma Renin Activity in Experimental Dilated Cardiomyopathy: Effects on Edema, Cachexia, and Survival.International journal of molecular sciences · 2019Article
- Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet-induced obesity.Obesity science & practice · 2019Article
- Sustained effect of glucagon on body weight and blood glucose: Assessed by continuous glucose monitoring in diabetic rats.PloS one · 2018Article
- Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats.Diabetology & metabolic syndrome · 2018Article
- SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.Nature cell biology · 2017Article
- Comparison of bioimpedance spectroscopy and X-Ray micro-computed tomography for total fat volume measurement in mice.PloS one · 2017Article
- Segmentation and quantification of adipose tissue by magnetic resonance imaging.Magma (New York, N.Y.) · 2016Review
- PreclinicalFrontiers in pharmacology · 2016Review
- Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research.American journal of translational research · 2016Article
- Fully-automated, high-throughput micro-computed tomography analysis of body composition enables therapeutic efficacy monitoring in preclinical models.International journal of obesity (2005) · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Numerous obesity studies have coupled murine models with non-invasive methods to quantify body composition in longitudinal experiments, including X-ray computed tomography (CT) or quantitative nuclear magnetic resonance (QMR). Both microCT and QMR have been separately validated with invasive techniques of adipose tissue quantification, like post-mortem fat extraction and measurement. Here we report a head-to-head study of both protocols using oil phantoms and mouse populations to determine the parameters that best align CT data with that from QMR. First, an in vitro analysis of oil/water mixtures was used to calibrate and assess the overall accuracy of microCT vs. QMR data. Next, experiments were conducted with two cohorts of living mice (either homogenous or heterogeneous by sex, age and genetic backgrounds) to assess the microCT imaging technique for adipose tissue segmentation and quantification relative to QMR. Adipose mass values were obtained from microCT data with three different resolutions, after which the data were analyzed with different filter and segmentation settings. Strong linearity was noted between the adipose mass values obtained with microCT and QMR, with optimal parameters and scan conditions reported herein. Lean tissue (muscle, internal organs) was also segmented and quantified using the microCT method relative to the analogous QMR values. Overall, the rigorous calibration and validation of the microCT method for murine body composition, relative to QMR, ensures its validity for segmentation, quantification and visualization of both adipose and lean tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.