Evidence map›Paper›PMID 25299668›Full record

Trial reportPloS one2014

Effects of combined calcium and vitamin D supplementation on insulin secretion, insulin sensitivity and β-cell function in multi-ethnic vitamin D-deficient adults at risk for type 2 diabetes: a pilot randomized, placebo-controlled trial.

Claudia Gagnon, Robin M Daly, André Carpentier, Zhong X Lu, Catherine Shore-Lorenti, Ken Sikaris, Sonia Jean, Peter R Ebeling

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 10 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 10 syntheses or guidelines pooled it, 144 citations in OpenAlex.

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  14. Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.The Journal of clinical endocrinology and metabolism · 2022
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Claudia GagnonDepartment of Medicine, NorthWest Academic Centre, The University of Melbourne, Western Health, Melbourne, Australia.
Robin M DalyDepartment of Medicine, NorthWest Academic Centre, The University of Melbourne, Western Health, Melbourne, Australia.
André CarpentierDepartment of Medicine, University of Sherbrooke, Sherbrooke, Canada.
Zhong X LuMelbourne Pathology, Melbourne, Australia; Department of Medicine, Monash University, Melbourne, Australia.
Catherine Shore-LorentiDepartment of Medicine, NorthWest Academic Centre, The University of Melbourne, Western Health, Melbourne, Australia.
Ken SikarisMelbourne Pathology, Melbourne, Australia.
Sonia JeanDepartment of Chronic Diseases Surveillance, Institut national de santé publique du Québec, Quebec City, Canada; Department of Medicine, Laval University, Quebec City, Canada.
Peter R EbelingDepartment of Medicine, NorthWest Academic Centre, The University of Melbourne, Western Health, Melbourne, Australia.
Western Health · AUMelbourne Clinic · AUMonash University · AUUniversité de Sherbrooke · CAUniversité Laval · CAUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo examine whether combined vitamin D and calcium supplementation improves insulin sensitivity, insulin secretion, β-cell function, inflammation and metabolic markers.

design6-month randomized, placebo-controlled trial.

participantsNinety-five adults with serum 25-hydroxyvitamin D [25(OH)D] ≤55 nmol/L at risk of type 2 diabetes (with prediabetes or an AUSDRISK score ≥15) were randomized. Analyses included participants who completed the baseline and final visits (treatment n = 35; placebo n = 45).

interventionDaily calcium carbonate (1,200 mg) and cholecalciferol [2,000-6,000 IU to target 25(OH)D >75 nmol/L] or matching placebos for 6 months. MEASUREMENTS: Insulin sensitivity (HOMA2%S, Matsuda index), insulin secretion (insulinogenic index, area under the curve (AUC) for C-peptide) and β-cell function (Matsuda index x AUC for C-peptide) derived from a 75 g 2-h OGTT; anthropometry; blood pressure; lipid profile; hs-CRP; TNF-α; IL-6; adiponectin; total and undercarboxylated osteocalcin.

resultsParticipants were middle-aged adults (mean age 54 years; 69% Europid) at risk of type 2 diabetes (48% with prediabetes). Compliance was >80% for calcium and vitamin D. Mean serum 25(OH)D concentration increased from 48 to 95 nmol/L in the treatment group (91% achieved >75 nmol/L), but remained unchanged in controls. There were no significant changes in insulin sensitivity, insulin secretion and β-cell function, or in inflammatory and metabolic markers between or within the groups, before or after adjustment for potential confounders including waist circumference and season of recruitment. In a post hoc analysis restricted to participants with prediabetes, a significant beneficial effect of vitamin D and calcium supplementation on insulin sensitivity (HOMA%S and Matsuda) was observed.

conclusionsDaily vitamin D and calcium supplementation for 6 months may not change OGTT-derived measures of insulin sensitivity, insulin secretion and β-cell function in multi-ethnic adults with low vitamin D status at risk of type 2 diabetes. However, in participants with prediabetes, supplementation with vitamin D and calcium may improve insulin sensitivity.

trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12609000043235.

Indexed as

Dietary SupplementsAdiponectinAdultAgedBlood GlucoseCalcium, DietaryCholecalciferolC-PeptideC-Reactive ProteinDiabetes Mellitus, Type 2FemaleHumansInsulinInsulin ResistanceInsulin-Secreting CellsInterleukin-6AdiponectinADIPOQ protein, humanBlood GlucoseCalcium, DietaryCholecalciferolC-PeptideC-Reactive ProteinIL6 protein, humanInsulinInterleukin-6OsteocalcinTumor Necrosis Factor-alpha

Identifiers

PMID25299668
PMCPMC4192133
OpenAlexW2012381109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.