SynthesisBMJ clinical evidence2014
Trigeminal neuralgia.
Synthesis in BMJ clinical evidence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 21 citations in OpenAlex.
- Acupuncture in patients with trigeminal neuralgia-an exploratory mixed methods trial.Frontiers in medicine · 2026Trial
- Neurovascular Compression Syndromes of Cranial Nerves: A Multidisciplinary Guide to Management.Brain sciences · 2026Review
- Trigeminal neuralgia: from clinical challenges to molecular insights.The journal of headache and pain · 2026Review
- Photobiomodulation Therapy in the Management of Orofacial Neuropathic Pain-WALT Position Paper 2026.Journal of clinical medicine · 2026Review
- Outcomes of microvascular decompression for trigeminal neuralgia: a retrospective analysis from a Mexican high-specialty center.Arquivos de neuro-psiquiatria · 2026Article
- Wrap technique for idiopathic trigeminal neuralgia: patient series.Journal of neurosurgery. Case lessons · 2025Article
- Microvascular decompression: a contemporary update.BMC surgery · 2025Review
- Application of Intraoperative Awake Anesthesia and Three-Dimensional Reconstruction Technique in Percutaneous Microballoon Compression for Trigeminal Neuralgia.Journal of pain research · 2025Article
- Contributing factors to pain-free outcome in trigeminal neuralgia following microvascular decompression.Surgical neurology international · 2025Article
- Trigeminal neuralgia: therapeutic strategies to restore quality of life.Journal of oral & facial pain and headache · 2024Review
- Intraoperative neurophysiological mapping of trigeminal nerve: A surgical advancement in neurovascular decompression.World neurosurgery: X · 2024Article
- A Prospective Study to Examine the Association of the Foramen Ovale Size with Intraluminal Pressure of Pear-Shaped Balloon in Percutaneous Balloon Compression for Trigeminal Neuralgia.Pain and therapy · 2021Article
- Article
- An Effective Phytoconstituent Aconitine: A Realistic Approach for the Treatment of Trigeminal Neuralgia.Mediators of inflammation · 2021Article
- Evaluation of the Potential Pharmacokinetic Interactions Between Vixotrigine and an Oral Contraceptive.Clinical drug investigation · 2020Article
- Review
- Trigeminal-mediated headshaking in horses: prevalence, impact, and management strategies.Veterinary medicine (Auckland, N.Z.) · 2019Review
- The association between auditory nerve neurovascular conflict and sudden unilateral sensorineural hearing loss.Laryngoscope investigative otolaryngology · 2018Article
- Review
- Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia.Drugs · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTrigeminal neuralgia is a sudden, unilateral, brief, stabbing, recurrent pain in the distribution of one or more branches of the fifth cranial nerve. Pain occurs in paroxysms, which can last from a few seconds to several minutes. The frequency of the paroxysms ranges from a few to hundreds of attacks a day. Periods of remission can last for months to years, but tend to shorten over time. The condition can impair activities of daily living and lead to depression. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of ongoing treatments in people with trigeminal neuralgia? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
resultsWe found seven studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
conclusionsIn this systematic review, we present information relating to the effectiveness and safety of the following interventions: baclofen; carbamazepine; gabapentin; lamotrigine; oxcarbazepine; microvascular decompression; and destructive neurosurgical techniques (radiofrequency thermocoagulation, glycerol rhizolysis, balloon compression, and stereotactic radiosurgery).
Indexed as
Identifiers
25299564PMC4191151W4302561478What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.