Evidence map›Paper›PMID 25299496›Full record

ReviewBiological research2014

CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast.

Laura García-Labastida, Raquel Garza-Guajardo, Oralia Barboza-Quintana, Irám Pablo Rodríguez-Sanchez, Jesús Ancer-Rodríguez, Juan Pablo Flores-Gutierrez, Gabriela Sofía Gómez-Macías

Open access · goldAbstract readReview
In one paragraph

Review in Biological research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Laura García-LabastidaUniversidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. hslaura@hotmail.com.
Raquel Garza-GuajardoUniversidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. rgguajardo@yahoo.com.
Oralia Barboza-QuintanaUniversidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. oralibarboza@gmail.com.
Irám Pablo Rodríguez-SanchezUniversidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. iramrodriguez@gmail.com.
Jesús Ancer-RodríguezUniversidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. jesus.ancer@uanl.mx.
Juan Pablo Flores-GutierrezUniversidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. jufloresmx@hotmail.com.
Gabriela Sofía Gómez-MacíasUniversidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. bpositivo66@hotmail.com.
Hospital Universitario Dr José Eleuterio Gonzalez · MXUniversidad Autónoma de Nuevo León · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma.

resultsTwenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2.

conclusionsThese results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.

Indexed as

Adenocarcinoma, MucinousAdultAgedAged, 80 and overAntigens, Differentiationbeta CateninBiomarkers, TumorBreast NeoplasmsCDX2 Transcription FactorFemaleHomeodomain ProteinsHumansImmunohistochemistryIntestinal MucosaMiddle AgedMucin-2Antigens, Differentiationbeta CateninBiomarkers, TumorCDX2 Transcription FactorHomeodomain ProteinsMUC2 protein, humanMucin-2Trans-Activators

Identifiers

PMID25299496
PMCPMC4177067
OpenAlexW2163349911

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.