ArticleACS nano2014
A complementary palette of NanoCluster Beacons.
Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Mechanistic insights into the color transformation of a non-FRET substrate for RNase activity detection.bioRxiv : the preprint server for biology · 2026Article
- Fluorescent Silver Nanoclusters Associated with Double-Stranded Poly(dGdC) DNA.Nanomaterials (Basel, Switzerland) · 2025Article
- Recent Advances of Strategies and Applications in Aptamer-Combined Metal Nanocluster Biosensing Systems.Biosensors · 2024Review
- Interactions of coinage metal nanoclusters with low-molecular-weight biocompounds.Biophysical reviews · 2024Review
- A non-FRET DNA reporter that changes fluorescence colour upon nuclease digestion.Nature nanotechnology · 2024Article
- Recent Advances in Single-Molecule Tracking and Imaging Techniques.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023Review
- Massively Parallel Selection of NanoCluster Beacons.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Biomarker sensing platforms based on fluorescent metal nanoclusters.Nanoscale advances · 2021Review
- Structure and luminescence of DNA-templated silver clusters.Nanoscale advances · 2021Review
- The spatial organization of trace silver atoms on a DNA template.RSC advances · 2020Review
- Development of dual-emission cluster of Ag atoms for genetically modified organisms detection.Mikrochimica acta · 2020Article
- The Fluorescent Palette of DNA-Templated Silver Nanoclusters for Biological Applications.Frontiers in chemistry · 2020Review
- Footprints of Nanoscale DNA-Silver Cluster ChromophoresACS nano · 2019Article
- Atomic Structure of a Fluorescent AgJournal of the American Chemical Society · 2019Article
- Article
- A Nanobiosensor Based on Fluorescent DNA-Hosted Silver Nanocluster and HCR Amplification for Detection of MicroRNA Involved in Progression of Multiple Sclerosis.Journal of fluorescence · 2017Article
- LNA Thymidine Monomer Enables Differentiation of the Four Single-Nucleotide Variants by Melting Temperature.Journal of the American Chemical Society · 2017Article
- Split Spinach Aptamer for Highly Selective Recognition of DNA and RNA at Ambient Temperatures.Chembiochem : a European journal of chemical biology · 2016Article
- A Segregated, Partially Oxidized, and Compact Ag10 Cluster within an Encapsulating DNA Host.Journal of the American Chemical Society · 2016Article
- NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection.Nanoscale · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
NanoCluster Beacons (NCBs), which use few-atom DNA-templated silver clusters as reporters, are a type of activatable molecular probes that are low-cost and easy to prepare. While NCBs provide a high fluorescence enhancement ratio upon activation, their activation colors are currently limited. Here we report a simple method to design NCBs with complementary emission colors, creating a set of multicolor probes for homogeneous, separation-free detection. By systematically altering the position and the number of cytosines in the cluster-nucleation sequence, we have tuned the activation colors of NCBs to green (C8-8, 460 nm/555 nm); yellow (C5-5, 525 nm/585 nm); red (C3-4, 580 nm/635 nm); and near-infrared (C3-3, 645 nm/695 nm). At the same NCB concentration, the activated yellow NCB (C5-5) was found to be 1.3 times brighter than the traditional red NCB (C3-4). Three of the four colors (green, yellow, and red) were relatively spectrally pure. We also found that subtle changes in the linker sequence (down to the single-nucleotide level) could significantly alter the emission spectrum pattern of an NCB. When the length of linker sequences was increased, the emission peaks were found to migrate in a periodic fashion, suggesting short-range interactions between silver clusters and nucleobases. Size exclusion chromatography results indicated that the activated NCBs are more compact than their native duplex forms. Our findings demonstrate the unique photophysical properties and environmental sensitivities of few-atom DNA-templated silver clusters, which are not seen before in common organic dyes or luminescent crystals.
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Registered trials
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