Evidence map›Paper›PMID 25299326›Full record

ArticleCell host & microbe2014

A delicate balance: maintaining mutualism to prevent disease.

Daria Van Tyne, Michael S Gilmore

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Predictable Molecular Adaptation of CoevolvingFrontiers in microbiology · 2018
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Daria Van TyneDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Michael S GilmoreDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: michael_gilmore@meei.harvard.edu.
Massachusetts Eye and Ear Infirmary · US

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
E. faecalis Pathogenicity IslandR01AI072360 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI GILMORE, MICHAEL S · 2007 to 2017
$3.8M
Enterococcal Pathogenesis:Role of CytolysinR01AI108710 · NIAID · MASSACHUSETTS EYE AND EAR INFIRMARY · PI GILMORE, MICHAEL S · 2013 to 2017
$2.0M
Bacterial Evasion of Innate Defenses at the Ocular SurfaceR00EY028222 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2018 to 2020
$728k
Regulation of Expression and Immunity in the Enterococcus Faecalis CytolysinF32AI109855 · NIAID · MASSACHUSETTS EYE AND EAR INFIRMARY · PI VAN TYNE, DARIA N · 2014 to 2016
$108k
NEI NIH HHS R00 EY028222NIAID NIH HHS AI072360NIAID NIH HHS AI083214NIAID NIH HHS AI108710NIAID NIH HHS AI109855NIAID NIH HHS F32 AI109855NIAID NIH HHS P01 AI083214NIAID NIH HHS R01 AI072360NIAID NIH HHS R01 AI108710
6 · The paper itself

Abstract

The intestinal microbial ecosystem is complex, and few of the principles that contribute to homeostasis in health are well understood. Pham et al. (2014) show that a network including the epithelial interleukin-22 receptor protects against infection with the opportunistic pathogen Enterococcus faecalis through promotion of host-microbiota mutualism.

Indexed as

Animals

Identifiers

PMID25299326
PMCPMC4489553
OpenAlexW2075102403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.